Polymorphism

IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis

X. B. Bao, Ma, Z., Gu, J. B., Wang, X. Q., Li, H. G., and Wang, W. Y., IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis, vol. 14, pp. 1508-1514, 2015.

We conducted a case-control study to clarify the asso­ciations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis. Genotyping analyses of IL-1β+3954 C/T (rs1143634), IL-1β-511 C/T (rs16944), IL-6 -174 G/C (rs1800795), IL-6 -634 C/G (rs1800796), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were conducted using polymerase chain reaction-restriction fragment length of polymorphism.

Analysis of the genetic effects of CAPN1 gene polymorphisms on chicken meat tenderness

J. T. Shu, Zhang, M., Shan, Y. J., Xu, W. J., Chen, K. W., and Li, H. F., Analysis of the genetic effects of CAPN1 gene polymorphisms on chicken meat tenderness, vol. 14, pp. 1393-1403, 2015.

The micromolar calcium-activated neutral protease gene (CAPN1) is a physiological candidate gene for meat tenderness. Four previously identified single nucleotide polymorphism (SNP) markers located within the CAPN1 gene were evaluated for their associations with variation in the meat tenderness of a Chinese indigenous chicken breed, a higher meat quality breed (i.e., Qingyuan partridge chicken), and the commercial Recessive White chicken breed.

Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

H. Liu, Ma, H. F., and Chen, Y. K., Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis, vol. 14, pp. 1385-1392, 2015.

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a random-effect model to pool the odds ratios (ORs) and 95% confidence intervals (CIs).

Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

Y. Liu, Yu, M. C., Zhang, A. Q., Wang, Y. B., Jiang, K., and Dong, J. H., Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis, vol. 14, pp. 1229-1234, 2015.

We conducted a hospital-based case-control study to assess the association between IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G polymorphisms and the risk of liver cirrhosis in a Chinese population. This 1:1-matched case-control study included 192 patients from the Chinese PLA General Hospital. Genotypes of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G were detected by polymerase chain reaction amplification-restriction fragment length polymorphism analysis.

Genetic diversity and phylogenetic relationship among Tunisian cactus species (Opuntia) as revealed by random amplified microsatellite polymorphism markers

B. M. Zarroug, Baraket, G., Zourgui, L., Souid, S., and A. Hannachi, S., Genetic diversity and phylogenetic relationship among Tunisian cactus species (Opuntia) as revealed by random amplified microsatellite polymorphism markers, vol. 14, pp. 1423-1433, 2015.

Opuntia ficus indica is one of the most economically important species in the Cactaceae family. Increased interest in this crop stems from its potential contribution to agricultural diversification, application in the exploitation of marginal lands, and utility as additional income sources for farmers. In Tunisia, O. ficus indica has been affected by drastic genetic erosion resulting from biotic and abiotic stresses. Thus, it is imperative to identify and preserve this germplasm.

Genetic diversity of Qatari date palm using SSR markers

K. Elmeer and Mattat, I., Genetic diversity of Qatari date palm using SSR markers, vol. 14, pp. 1624-1635, 2015.

The genetic diversity in the date palm germplasm of 59 female accessions representing 12 cultivars from different locations in Qatar was investigated using 14 loci of simple-sequence repeat (SSR) primers. A total of 94 alleles, with a mean of 6.7 alleles per locus, were scored. The number of alleles per locus varied from 3 (primer mPdCIR090) to 11 (primers mPdCIR010 and mPdCIR015). The amplified SSR band sizes ranged from 104 to 330 bp.

Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease

S. Sahin, Ceyhan, K., Benli, I., Ozyurt, H., Naseri, E., Tumuklu, M. M., Aydogan, L., Elalmis, A. O., Ozugurlu, A. F., and Onalan, O., Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease, vol. 14, pp. 2063-2068, 2015.

We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene polymorphism, and ACE serum levels were compared. ACE genotypes were determined using real-time polymerase chain reaction.

Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population

Y. Z. Dong, Huang, Y. X., and Lu, T., Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population, vol. 14, pp. 1899-1902, 2015.

In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = 0.011). We also found that the C allele was more common in osteosarcoma patients than that in control subjects (P = 0.004).

EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population

J. H. Torres-Jasso, Marín, M. E., Santiago-Luna, E., Leoner, J. C., Torres, J., Magaña-Torres, M. T., Perea, F. J., Ibarra, B., and Sánchez-López, J. Y., EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population, vol. 14, pp. 1802-1807, 2015.

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>T, -191C>A, and (CA)n first intervening sequence (IVS1) have been related to EGFR overexpression and have been studied in several types of cancer, but not in gastric cancer (GC).

Isolation and characterization of polymorphic microsatellite loci for Pachycrepoideus vindemmiae (Rondani) (Hymenoptera: Pteromalidae)

W. Chen, Fang, L., Liu, J. L., He, Z., and Hu, H. Y., Isolation and characterization of polymorphic microsatellite loci for Pachycrepoideus vindemmiae (Rondani) (Hymenoptera: Pteromalidae), vol. 14, pp. 1798-1801, 2015.

The parasitoid wasp Pachycrepoideus vindemmiae (Rondani) is a common pupal parasitoid of many fly pests that is distributed worldwide. This organism can be used for biological control in orchards or livestock farms. Identifying polymorphic microsatellite loci would be useful for analyzing the population genetic structure of the parasitoid. In the current study, based on a modified biotin-capture method, 10 polymorphic microsatellite loci were isolated and characterized for the insect, 7 of which did not deviate from Hardy-Weinberg equilibrium.

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