Polymorphism

Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer

J. M. He, Pu, Y. D., Wu, Y. J., Qin, R., Zhang, Q. J., Sun, Y. S., Zheng, W. W., and Chen, L. P., Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer, vol. 13, pp. 8925-8931, 2014.

We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were calculated, and the MTHFR C677T and A1298C and MTR A2756G polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism.

Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province

S. X. Guo, Guo, H., Ma, R. L., Ding, Y. S., Zhang, J. Y., Liu, J. M., Zhang, M., Niu, Q., Qiang, N., Li, S. G., and Qi, C. N., Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province, vol. 13, pp. 8686-8694, 2014.

We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients and 244 controls) using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.

Genetic diversity of Y-short tandem repeats in chinese native cattle breeds

Y. P. Xin, Zan, L. S., Liu, Y. F., Tian, W. Q., Wang, H. B., Cheng, G., Li, A. N., and Yang, W. C., Genetic diversity of Y-short tandem repeats in chinese native cattle breeds, vol. 13, pp. 9578-9587, 2014.

The aim of this study is to use Y-chromosome gene polymorphism method to investigate regional differences in genetic variation and population evolution history of the Chinese native cattle breeds. Six Y-chromosome short tandem repeat (Y-STR) loci (UMN0929, UMN0108, UMN0920, INRA124, UMN2404, and UMN0103) were analyzed using 1016 healthy and heterogenetic males and 90 females of 9 native cattle breeds (Qinchuan, Jinnan, Zaosheng, Luxi, Nanyang, Jiaxian, Dabieshan, Yanbian, and Menggu) in China.

Relationship between the TaqI B polymorphism of the cholesterol ester transfer protein gene and atrial fibrillation in Han and Kazak populations

M. Bakeyi, Wulasihan, M., Lu, W. H., Yang, Y. C., Li, J., Liu, Z. Q., and He, P. Y., Relationship between the TaqI B polymorphism of the cholesterol ester transfer protein gene and atrial fibrillation in Han and Kazak populations, vol. 13, pp. 9300-9307, 2014.

The TaqI B polymorphism in the cholesterol ester transfer protein (CETP) (B1 and B2 alleles; rs708272) is associated with changes in enzyme activity and lipid concentrations. The B1 allele of the CETP gene is a known independent risk factor for genetic susceptibility to atrial fibrillation (AF); however, little is known about this polymorphism in the minority groups of Xinjiang, China.

MULTINDELS-BOV: Zebu traceback method based on DNA insertion-deletion polymorphisms

M. Groenner-Penna, Croce, E. F. D., Pimenta, C. G., Bicalho, H. M. S., and Pena, S. D. J., MULTINDELS-BOV: Zebu traceback method based on DNA insertion-deletion polymorphisms, vol. 13, pp. 9171-9186, 2014.

Brazil is a major producer and exporter of beef, with a herd of approximately 210 million animals. For the meat industry, a reliable animal traceback from its origin to the consumer market is paramount. Of all available identification systems, DNA is the only one that survives the slaughterhouse and reaches the dish of the consumer. DNA polymorphisms are already used for cattle traceback, but primarily for the subspecies Bos taurus taurus. However, in Brazil, another subspecies, B. taurus indicus predominates.

Association of VDR polymorphisms with type 2 diabetes mellitus in Chinese Han and Hui populations

J. R. Xu, Yang, Y., Liu, X. M., and Wang, Y. J., Association of VDR polymorphisms with type 2 diabetes mellitus in Chinese Han and Hui populations, vol. 13, pp. 9588-9598, 2014.

We investigated the association between vitamin D receptor (VDR) and susceptibility to type 2 diabetes mellitus (T2DM). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was conducted to examine single nucleotide polymorphisms (SNPs) of the rs1544410 (BsmI, G>A), rs757343 (Tru9I, G>A), rs731236 (TaqI, T>C), and rs739837 (BglI, G>T) loci of the VDR gene in 334 healthy individuals (Hui 115, Han 219) and 355 T2DM patients (Hui 154, Han 201) living in the Ningxia Hui Autonomous Region of China.

Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis

Y. Kong, Wu, J. B., Wang, X., Zhao, J. F., Song, H., and Yuan, L. D., Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis, vol. 13, pp. 10162-10172, 2014.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'-untranslated region of the gene and may influence the binding of regulatory microRNAs (miRNAs) and OLR1 protein homeostasis. A number of studies have reported an association between this variant and AD.

Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis

L. Li, Wang, S. J., Shi, K., Chen, D., Jia, H., and Zhu, J., Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis, vol. 13, pp. 10150-10161, 2014.

Several studies have found that microsomal transfer protein (MTP) may be important in the development and progression of non-alcoholic fatty liver disease (NAFLD). In this meta-analysis, we evaluated the relationships between a common polymorphism (-493G>T, rs1800591 G>T) in the MTP gene and NAFLD risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before October 1, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software.

Examination of polymorphism in hybrid wheat by using amplified fragment length polymorphism marker

M. Ejaz, Gaisheng, Z., Quidi, Z., Qunzhu, W., and Huiyan, Z., Examination of polymorphism in hybrid wheat by using amplified fragment length polymorphism marker, vol. 13, pp. 10076-10085, 2014.

To investigate the polymorphism of two groups of male sterile lines and their maintainer lines, we used amplified fragment length polymorphism markers. Of the 64 primer pairs, five reproducibly demonstrated polymorphism. Group I had 27 polymorphic bands, and Group II had 24 polymorphic bands. The maximum number of polymorphic bands was produced by line 2 (18 polymorphic bands) followed by line 7 (15 polymorphic bands).

Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma

N. B. Costa, Silva, C. T. X., Frare, A. B., Silva, R. E., and Moura, K. K. V. O., Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma, vol. 13, pp. 10382-10389, 2014.

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as primary open-angle glaucoma.

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