Polymorphism

Association between the LXRα polymorphism and stroke in a Chinese population

J. S. Yang, Hao, J. J., Wang, S. S., Zhu, Z. F., Fang, Q., Bao, H., and Zhang, H. P., Association between the LXRα polymorphism and stroke in a Chinese population, vol. 14, pp. 1757-1762, 2015.

We examined the relationship between the liver X receptor α gene (LXRα) polymorphism and the susceptibility to stroke. We utilized the single fluorescent-labeled probe technique to detect the genotype of rs12221497 in the LXRα gene in 400 stroke patients and 400 healthy control subjects. The difference in genotype distribution between the 2 groups was analyzed using the chi-square test. Serum lipids and glucose levels between the different genotypes were also compared.

Effect of a pre-microRNA-149 (miR-149) genetic variation on the risk of ischemic stroke in a Chinese Han population

Q. Y. Chen, Liu, N., Ma, J., Fang, Y., Cao, Y., Li, H., and Liu, Y. C., Effect of a pre-microRNA-149 (miR-149) genetic variation on the risk of ischemic stroke in a Chinese Han population, vol. 14, pp. 2582-2589, 2015.

Clinical and experimental data have demonstrated that genetic factors play an important role in determining the susceptibility to ischemic stroke (IS). The present study was performed to clarify the association between the pre-microRNA-149 (miR-149) single nucleotide polymorphism rs71428439 and the risk of IS in the Jiangsu Han population. Polymerase chain reaction and restriction fragment length polymorphism were performed to identify the genotypes of the miR-149 single-nucleotide polymorphism rs71428439 in 730 unrelated subjects (IS, 348; healthy controls, 382).

Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes

Y. L. Chen, Pei, D., Hung, Y. J., Lee, C. H., Hsiao, F. C., Wu, C. Z., Lin, J. D., Hsu, C. H., Chang, J. B., and Hsieh, C. H., Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes, vol. 14, pp. 2518-2526, 2015.

Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjects. A total of 240 T2D subjects aged 35-64 years were recruited. Waist circumstance, plasma triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, and blood pressure were measured to define MetS.

Sexual genetic and simple sequence repeat (SSR) analysis for molecular marker development on the all hermaphrodite papaya

C. T. Chiu, Wang, C. W., Chen, F. C., Chin, S. W., Liu, C. C., Lee, M. J., Chung, W. C., Chien, Y. W., Chang, H. J., and Lee, C. Y., Sexual genetic and simple sequence repeat (SSR) analysis for molecular marker development on the all hermaphrodite papaya, vol. 14, pp. 2502-2511, 2015.

The papaya (Carica papaya L.) is one of the most important economic tropical fruits in the world, and the hermaphrodite is the preferred type in field cultures. We analyzed the sexual ratio of offspring from the cultivar ‘Taiwan Seed Station No. 7’ (T7) by a self-cross and its cross with Taichung Sunrise (TS). Female progeny from the T7 self-crossing were not observed. This finding may be caused by a lethal gene that is linked to females. In this study, we selected 192 simple sequence repeats (SSRs) to analyze the polymorphism between T7 and TS.

Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle

H. Y. Chung, Choi, Y. J., Park, H. N., and Davis, M. E., Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle, vol. 14, pp. 3026-3035, 2015.

In this study, we investigated the associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle. Polymerase chain reaction primers were based on GenBank accession No. AF404761 and amplified approximately 533-bp segments. Newly identified sequences were submitted to GenBank (accession No. DQ267493).

Association of the IL-4R Q576R polymorphism and asthma in the Chinese Han population: A meta-analysis

Z. Y. Huang, Cheng, B. J., Cai, G. J., and Zhang, B. F., Association of the IL-4R Q576R polymorphism and asthma in the Chinese Han population: A meta-analysis, vol. 14, pp. 2900-2911, 2015.

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R Q576R polymorphism and asthma in the Chinese Han population were obtained by comprehensive literature search incorporating electronic databases, and included 2077 asthma cases and 1589 controls.

Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk

C. X. Zhou and Zhao, J. H., Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk, vol. 14, pp. 2868-2875, 2015.

Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We searched for relevant studies in both Chinese and English in PubMed, Web of Science, Cochrane Library, and EMBASE through January 1, 2014, and identified 3939 cases and 5407 controls.

Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis

Y. Song, Gu, H. D., He, Y., and Wang, J. W., Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis, vol. 14, pp. 2631-2637, 2015.

We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By multivariate analysis, we found that the IL-6 -634GG genotype was associated with increased risk of cardiovascular events in patients receiving hemodialysis, with HR (95%CI) of 4.07 (1.20-15.70).

Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens)

M. Chu, Wu, X. Y., Guo, X., Pei, J., Jiao, F., Fang, H. T., Liang, C. N., Ding, X. Z., Bao, P. J., and Yan, P., Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens), vol. 14, pp. 2617-2625, 2015.

Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing techniques. SNP g.5477C>T is located in intron 3 of FASN, and 3 genotypes, HH, HG, and GG, were detected in this mutation site.

IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

J. Xu, Xu, L., Li, L. T., You, Q., and Cha, L. S., IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies, vol. 14, pp. 3370-3386, 2015.

Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratios (OR) with 95% confidence interval (CI) were calculated.

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