Polymorphism

Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease

K. Wang, Dong, P. S., Zhang, H. F., Li, Z. J., Yang, X. M., and Liu, H., Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease, vol. 14, pp. 3177-3183, 2015.

We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 ˗174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain reaction-restriction fragment length polymorphism.

Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China

L. Yang, Wang, J., Li, F. - G., Han, M., Chang, X. - J., and Wang, Z. - T., Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China, vol. 14, pp. 3745-3752, 2015.

Lung cancer is a common malignant tumor worldwide and is now the leading cause of cancer-related deaths. Monocyte chemoattractant protein 1 (MCP-1) and its receptor chemokine receptor 2 (CCR-2) are important chemokines. We examined the polymorphisms of 338 unrelated patients with non-small cell lung carcinoma (NSCLC) and 200 unrelated healthy controls of Han nationality in Northern China using polymerase chain reaction-restriction fragment length polymorphism.

Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients

H. B. Wang, Song, W. G., Liu, H. Q., Fang, F., and Xiao, Y., Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients, vol. 14, pp. 3545-3550, 2015.

We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Odds ratios and their corresponding 95% confidence intervals were used to assess the influence of TGFB1 rs4803455, rs1800469, and rs1800470 on metastatic brain tumors.

Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis

M. Xiao, Wang, T., Zhu, T., and Wen, F., Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis, vol. 14, pp. 3534-3540, 2015.

Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the Pubmed, Embase, and China National Knowledge Infrastructure databases. After data extraction, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Seven case-control studies were included.

Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis

J. H. Qi, Shi, N., Chen, Y. J., and Nie, G., Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis, vol. 14, pp. 3869-3876, 2015.

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T polymorphism and psoriasis risk were retrieved from the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases.

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

R. Zhu, Bi, L. Q., Kong, H., Tilley, S. L., Wang, H., and Xie, W. P., Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk, vol. 14, pp. 3590-3600, 2015.

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval.

Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population

Q. - Q. Lv, Lu, J., Sun, H., and Zhang, J. - S., Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population, vol. 14, pp. 4161-4168, 2015.

The association between the MTHFR genetic polymorphism and ischemic stroke has been reported by a number of investigators. However, the results have been controversial and conflicting. The aim of this study was to explore the association between the MTHFR variants C677T and A1298C and the risk of ischemic stroke in an Eastern Chinese Han population. A total of 199 patients with ischemic stroke and 241 controls were recruited. Genotyping of the MTHFR C677T and A1298C polymorphisms was carried out using the Taqman 7900HT Sequence Detection System.

Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population

P. He, Chen, X. L., and Ding, Y. P., Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population, vol. 14, pp. 4142-4149, 2015.

We investigated the association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction (ACI) in a Chinese Han population of Hainan Province. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to analyze the distribution of APM-1 +45T/G and +276G/T genotypes and their alleles in 120 ACI patients and 120 healthy controls. No statistical correlation was found in the frequency and distribution of the genotype 45T/G between the ACI group and the control group.

Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma

J. H. Zhong, Li, L. Q., Mo, X. S., Gong, W. F., Ma, L., Chen, J., and You, X. - M., Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma, vol. 14, pp. 4133-4141, 2015.

Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma risk. We searched the PubMed, EMBASE, and Google Scholar databases to identify relevant studies.

Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population

S. G. Liu, Ma, L., Cen, Q. H., Huang, J. S., Zhang, J. X., and Zhang, J. J., Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population, vol. 14, pp. 4469-4476, 2015.

Genome-wide association studies in several ethnic groups have reported that polymorphisms of the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes, located on 5p15.33, are associated with susceptibility to lung cancer. However, whether genetic variants of TERT-CLPTM1L are associated with an increased risk of lung cancer in the Chinese Han population is unknown.

Pages

Subscribe to Polymorphism