Polymorphism

Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population

Q. - Q. Lv, Lu, J., Sun, H., and Zhang, J. - S., Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population, vol. 14, pp. 4161-4168, 2015.

The association between the MTHFR genetic polymorphism and ischemic stroke has been reported by a number of investigators. However, the results have been controversial and conflicting. The aim of this study was to explore the association between the MTHFR variants C677T and A1298C and the risk of ischemic stroke in an Eastern Chinese Han population. A total of 199 patients with ischemic stroke and 241 controls were recruited. Genotyping of the MTHFR C677T and A1298C polymorphisms was carried out using the Taqman 7900HT Sequence Detection System.

Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis

G. Q. Zhou, Meng, H., Wang, J. R., Sun, F. X., Wang, X. J., Wang, R. B., and Wang, X. B., Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis, vol. 14, pp. 4767-4777, 2015.

Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk. A digital search was performed of the MEDLINE EMBASE, CNKI, and CBM databases to identify relevant articles published up to February 18, 2014.

Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer

L. Zhang, Xi, R. - X., and Zhang, X. - Z., Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer, vol. 14, pp. 4616-4624, 2015.

We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age- and gender-matched healthy controls were enrolled in this study.

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Y. S. Wang, Liu, L., Xu, X. Y., Wang, J. L., Zhou, H., Li, T. L., and Liang, Z. A., Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis, vol. 14, pp. 4477-4484, 2015.

Studies examining the role of interleukin (IL)-1β -511C/T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This meta-analysis was performed to assess the association between the IL-1β-511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sectional, and cohort studies from Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment

M. Luo, Zhou, X. H., Zou, T., Keyim, K., and Dong, L. M., Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment, vol. 14, pp. 5407-5416, 2015.

We investigated type II deiodinase (DIO2) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms of 129 unrelated MCI cases and 131 matched controls. All subjects were genotyped using SNaPshot SNP genotyping assays. Serum thyroid hormone levels were measured by radioimmunoassay. Levels of serum triiodothyronine and thyroxine in the MCI group were significantly lower than those in the control group.

Investigation of TG gene variants and their effects on growth, carcass composition, and meat quality traits in Chinese steers

L. P. Zhang, Gan, Q. F., Hou, G. Y., Gao, H. J., Li, J. Y., and Xu, S. Z., Investigation of TG gene variants and their effects on growth, carcass composition, and meat quality traits in Chinese steers, vol. 14, pp. 5320-5326, 2015.

Thyroid hormones play an important role in regulating metabolism and can affect metabolism-related traits such as fat deposition. The thyroglobulin (TG) gene produces the precursor of thyroid hormones and has been proposed as a candidate gene for a quantitative trait locus with an effect on fat deposition. In this study, we identified 4 novel single nucleotide polymorphisms (SNPs) in the 5' flanking region of the TG gene using a DNA sequencing method.

Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis

K. Cui, Ge, X. Y., and Ma, H. L., Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis, vol. 14, pp. 5210-5220, 2015.

The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify articles that have reported an association between the TNF-α +489 G/A polymorphism and COPD risk.

CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis

X. Wang and He, Y., CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis, vol. 14, pp. 5203-5209, 2015.

Cytochrome P4502E1 (CYP2E1) is a key enzyme in the metabolic activation of many carcinogens, but the roles of CYP2E1 polymorphisms in cervical neoplasia (CN) are inconclusive. Published case-control cohort studies from the Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios with 95% confidence intervals were calculated. Seven studies examining 1097 cases and 1117 controls were included in this meta-analysis.

Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

Y. Zhao, He, H. R., Wang, M. Y., Ren, X. D., Zhang, L., Dong, Y. L., and Lu, J., Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis, vol. 14, pp. 5171-5180, 2015.

Cyclin D1 (CCND1) is a key protein involved in cell-cycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to clarify these associations. A search of the PubMed database yielded 7 relevant articles: 3 pertaining to leukemia and 4 to HCC. The odds ratios (ORs) from individual studies were pooled using a fixed or random-effect model.

TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis

Y. H. Lee and Song, G. G., TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis, vol. 14, pp. 4966-4977, 2015.

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A al­lele and glaucoma [odds ratio (OR) = 1.403, 95% confidence inter­val (CI) = 0.784-2.513, P = 0.254].

Pages

Subscribe to Polymorphism