Polymorphism

Development of novel microsatellite markers in the Korean rockfish Sebastes schlegeli

H. - T. Ma, Jia, C. - F., Yang, J. - M., Wang, F., Xue, R., Han, C. - H., and Jiang, H. - B., Development of novel microsatellite markers in the Korean rockfish Sebastes schlegeli, vol. 14, pp. 5099-5102, 2015.

The Korean rockfish Sebastes schlegeli is a valuable recreational and commercial fish in China, and is cultured in land-based tanks and net cages. Fifteen microsatellite markers were developed for this species, and their polymorphisms were examined in a population. The allele number of the 15 markers ranged from 2 to 13, with an average of 5.933 per locus. The observed and expected heterozygosity values ranged from 0.063 to 0.938 (averaging 0.585), and 0.062 to 0.908 (averaging 0.642), respectively.

Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis

R. Yao, Du, Y. Y., Zhang, Y. Z., Chen, Q. H., Zhao, L. S., and Li, L., Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis, vol. 14, pp. 5527-5534, 2015.

Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature search of the Google Scholar, PubMed, and China National Knowledge Infrastructure databases for relevant studies that examined the G-217A polymorphism and risk of essential hypertension.

Associations between TNF-α polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis

Y. H. Lee and Bae, S. C., Associations between TNF-α polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis, vol. 14, pp. 5548-5559, 2015.

We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls. Meta-analysis was used to examine the associations between the TNF-α -238 A/G polymorphism and RA and vitiligo using the allelic contrast and dominant models.

Development and characterization of microsatellite markers via cross-species amplification of Paramisgurnus dabryanus

G. Chen, Huang, S., Gao, J., Bai, X., Wang, W., and Cao, X., Development and characterization of microsatellite markers via cross-species amplification of Paramisgurnus dabryanus, vol. 14, pp. 5694-5698, 2015.

The large-scale loach, Paramisgurnus dabryanus, is a small freshwater fish of major economic importance in many Asian countries, particularly China and South Korea. Fifteen polymorphic microsatellite (simple sequence repeat) markers were obtained through cross-species amplification between this loach and a related species, Misgurnus anguillicaudatus (GenBank accession numbers: KC117456 to KC117470). The number of alleles per locus ranged from 5 to 12 among 40 individuals, and the average observed and expected heterozygosities were 0.344 and 0.828, respectively.

Leptin and leptin receptor gene polymorphisms are correlated with production performance in the Arctic fox

M. Zhang and Bai, X. J., Leptin and leptin receptor gene polymorphisms are correlated with production performance in the Arctic fox, vol. 14, pp. 5560-5570, 2015.

The polymerase chain reaction-single-strand conforma­tion polymorphism technique was employed to measure mononucleo­tide diversity in the coding region of the leptin and leptin receptor genes in the Arctic fox. The relationships between specific genetic mutations and reproductive performance in Arctic foxes were determined to im­prove breeding strategies. We found that a leptin gene polymorphism was significantly associated with body weight (P

Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population

P. Qi, Wang, L., Zhou, B., Yao, W. J., Xu, S., Zhou, Y., and Xie, Z. B., Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population, vol. 14, pp. 6289-6296, 2015.

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A>G; miR-27a rs895819 A>G; miR-196a2 rs11614913 T>C; miR-146a rs2910164 G/C) were detected using Taqman assays.

Novel polymorphic microsatellite markers in Odontobutis potamophila

Y. B. Shen, Li, D., Li, J. L., Wang, R. Q., and Xuan, Y. F., Novel polymorphic microsatellite markers in Odontobutis potamophila, vol. 14, pp. 6265-6269, 2015.

We characterized 16 novel polymorphic loci isolated from a partial genomic DNA library of Odontobutis potamophila enriched for CA repeats. We tested the variability of these microsatellites on 51 unrelated individuals collected in China. All loci were polymorphic. The average allele number was 14.6 per locus, ranging from 2 to 27. The observed heterozygosity ranged from 0.35 to 0.90, with an average of 0.70, whereas the average expected heterozygosity was 0.76. Twelve of the 16 microsatellites conformed to Hardy-Weinberg equilibrium and were inherited independently.

 Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis

S. T. Ma, Zhao, W., Liu, B., Jia, R. Y., Zhao, C. J., and Cui, L. Q.,  Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis, vol. 14, pp. 5922-5929, 2015.

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, and China National Knowledge Infrastructure databases. Two reviewers independently assessed the studies.

Pterygium in patients from Goiânia, Goiás, Brazil

G. Mdos Reis, A. Júnior, deP. R., Silva, K. S. Fe, Rodrigues, D. A., Gomes, M. C. S., Martins, J. V. M., da Costa, I. R., Freitas, G. A., and Moura, K. K. O., Pterygium in patients from Goiânia, Goiás, Brazil, vol. 14, pp. 6182-6188, 2015.

Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously confused with cataract.

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

deP. R. A. Júnior, Reis, G. Mdos, Silva, K. S. Fe, Rodrigues, D. A., Gomes, M. C. S., Martins, J. V. M., da Costa, I. R., Freitas, G. A., and Moura, K. K. V. O., Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil, vol. 14, pp. 6173-6181, 2015.

The first reports about pterygium date back to Hip­pocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascular­ized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea.

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