Polymorphism

 Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis

S. T. Ma, Zhao, W., Liu, B., Jia, R. Y., Zhao, C. J., and Cui, L. Q.,  Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis, vol. 14, pp. 5922-5929, 2015.

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, and China National Knowledge Infrastructure databases. Two reviewers independently assessed the studies.

Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis

D. Li, Li, J., Wang, L., and Zhang, Q., Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis, vol. 14, pp. 6635-6641, 2015.

We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1β, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1β+3954C/T (rs1143634), IL-1β-511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were assessed by polymerase chain reaction-restriction fragment length polymorphism.

Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension

J. Jia, Men, C., Tang, K. - T., and Zhan, Y. - Y., Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension, vol. 14, pp. 6561-6568, 2015.

We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls.

Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population

H. D. Ye, Li, Y. R., Hong, Q. X., Zhou, A. N., Zhao, Q. L., Xu, L. M., Xu, M. Q., Xu, X. T., Tang, L. L., Dai, D. J., Jiang, D. J., Huang, Y., Wang, D. W., and Duan, S. W., Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population, vol. 14, pp. 6350-6359, 2015.

PPARD encodes peroxisome proliferator-activated re­ceptor delta, which has been shown to play an important role in control­ling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs2016520 polymorphism and coronary heart disease (CHD) in a Han Chinese population. A to­tal of 657 CHD cases and 640 controls were included in the associa­tion study. rs2016520 polymorphism genotyping was performed using the melting temperature-shift polymerase chain reaction method.

Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis

W. H. Zhai, Song, C. Y., Huang, Z. G., and Sha, H., Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis, vol. 14, pp. 7101-7112, 2015.

While increasing scientific evidence suggests that the ORMDL3 rs7216389 polymorphism may contribute to a higher susceptibility to asthma, many of the current studies have yielded inconclusive results. This meta-analysis aimed to assess the association between the ORMDL3 rs7216389 polymorphism and the risk of asthma. An extensive literature search for relevant studies was conducted in PubMed, Embase, the Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure, and Google Scholar. This meta-analysis was performed using the STATA 12.0 software.

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

Z. Li, Liu, Y., Cao, D., Jiang, M., and Luo, F., IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis, vol. 14, pp. 7008-7017, 2015.

We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 controls. Seven eligible case-control studies were selected, including seven studies on rs2275913G>A IL-17A and four studies on rs763780T>C IL-17F.

Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis

R. T. Sun, Tian, W. J., Xing, X. W., Gao, S. H., and Wang, S. B., Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis, vol. 14, pp. 6859-6864, 2015.

The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1βrs16944, IL8 rs4073, IL10 rs1800872, and IL10 rs1800896 was carried out using a 384-well plate format on the Sequenom MassARRAY platform.

Association between interleukin gene polymorphisms and risk of recurrent oral ulceration

C. Jing and Zhang, J. - Q., Association between interleukin gene polymorphisms and risk of recurrent oral ulceration, vol. 14, pp. 6838-6843, 2015.

We conducted a case-control study to investigate the association between the functional IL-1β+3954 (C/T), IL-6-174 (G/C), IL-10-1082 (G/A), and IL-10-819C/T genetic polymorphisms and risk of recurrent oral ulceration (ROU) in a Chinese population. Polymorphisms of IL-1β+3954C/T, IL-6-174G/C, IL-10-1082A/G and IL-10-819C/T were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-1β+3954 C/T and IL-10-819C/T were in Hardy-Weinberg equilibrium in the control group.

PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Y. H. Lee and Song, G. G., PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis, vol. 14, pp. 7248-7257, 2015.

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the apolipoprotein E (APOE) ɛ4 allele status. A total of eight studies were considered in our meta-analysis, comprising 2948 patients with AD and 3753 controls.

Novel non-synonymous polymorphisms in the COX-1 gene in Turkish pediatric patients with cardiovascular anomalies

I. Coskun, Colkesen, Y., Ayik, F., Berdeli, A., and Atay, Y., Novel non-synonymous polymorphisms in the COX-1 gene in Turkish pediatric patients with cardiovascular anomalies, vol. 13, pp. 262-268, 2014.

Variation in the gene encoding cyclooxygenase-1 (COX-1) is involved in the process of aspirin resistance. This study investigated the genetic variations in the COX-1 gene. The 4 coding regions of the human COX-1 gene in 90 pediatric patients (median age of 6.5 months, 55% males) with cardiovascular anomalies were screened using DNA sequencing. Twenty coding-region variants causing amino acid substitutions as well as 2 new non-synonymous polymorphisms were identified. All variants were compared with an independent Caucasian population (N = 24 unrelated individuals).

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