Polymorphism

Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population

L. Wang, Wang, Z. - T., Zhang, H. - X., Liu, J., Lu, S. - Y., Fan, R., Zhou, J., Xia, L., Sun, Y. - W., Zhong, J., and Yuan, Y. - Z., Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population, vol. 13, pp. 2343-2348, 2014.

Ulcerative colitis (UC) is a chronic inflammation of the large intestine. The aim of this study was to investigate the association of two polymorphisms in STAT3 with the risk of UC development in the Chinese Han population. This is a hospital-based case-control study involving 56 UC patients and 274 controls. Genotyping was performed using the polymerase chain reaction with sequence-specific primers (PCR-SSP) method. Statistical analyses were conducted using logistic regression and genotype risk score.

Characterization of EST-derived and non-EST simple sequence repeats in an F1 hybrid population of Vitis vinifera L.

E. Kayesh, Bilkish, N., Liu, G. S., Chen, W., Leng, X. P., and Fang, J. G., Characterization of EST-derived and non-EST simple sequence repeats in an F1 hybrid population of Vitis vinifera L., vol. 13, pp. 2220-2230, 2014.

Among different classes of molecular markers, expressed sequence tags (ESTs) are a new resource for developing simple sequence repeat (SSR) functional markers for genotyping and genetic mapping in F1 hybrid populations of Vitis vinifera L. Recently, because of the availability of an enormous amount of data for ESTs in the public domain, the emphasis has shifted from genomic SSRs to EST-SSRs, which belong to transcribed regions of the genome and may have a role in gene expression or function.

A new high-frequency allele of the BM2113 locus in the Yunnan mithun population

K. - X. Qu, He, Z. - X., Hao, R. - J., Zhang, J. - C., Huang, B. - Z., Zan, L. - S., and Zhang, Y. - P., A new high-frequency allele of the BM2113 locus in the Yunnan mithun population, vol. 13, pp. 2155-2159, 2014.

The BM2113 locus was amplified in Yunnan mithun (Bos frontalis) from the southwest mountains of China. It showed a high degree of polymorphism with a total of 12 alleles. The 121-bp polymorphic allele of the BM2113 locus that accounted for 37.1% of homozygotes was the predominant allele with a frequency of 58.57%, identified as mithun-specific for Bos species in Yunnan mithun.

Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer

X. P. Huang, Zhou, W. H., and Zhang, Y. F., Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer, vol. 13, pp. 2107-2119, 2014.

Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 15th, 2013. This meta-analysis was performed using the STATA 12.0 software.

Karyotypic diversity in a population of Bryconamericus aff. iheringii (Characidae)

L. L. L. da Silva, Giuliano-Caetano, L., and Dias, A. L., Karyotypic diversity in a population of Bryconamericus aff. iheringii (Characidae), vol. 13, pp. 2069-2081, 2014.

Bryconamericus comprises 56 species distributed into three groups, on the basis of the position and shape of the maxillary teeth: B. exodon, B. microcephalus and B. iheringii groups. Few cytogenetic data are available for this genus, but the diploid number of 52 chromosomes is quite common, although the karyotypic variability is extensive. This study aimed to characterize a population of B. aff. iheringii and thus contribute more cytogenetic information and better understanding of the structure and karyotypic evolution of this genus.

Isolation and characterization of polymorphic microsatellite loci of the Chinese muntjac (Muntiacus reevesi)

H. Wang, Luo, X., Shi, W. B., and Zhang, B. W., Isolation and characterization of polymorphic microsatellite loci of the Chinese muntjac (Muntiacus reevesi), vol. 13, pp. 1905-1908, 2014.

Eight polymorphic microsatellite markers for Muntiacus reevesi were identified and characterized in this study. The number of alleles per locus ranged from 3 to 10 across 24-48 samples. The loci showed expected and observed heterozygosities of 0.577-0.876 and 0.387-0.933, respectively, with an average polymorphic information content value of 0.682. These markers should be a useful tool for further population and conservation genetic studies of Muntiacus reevesi.

Investigation of the association of two candidate genes (H-FABP and PSMC1) with growth and carcass traits in Qinchuan beef cattle from China

W. Liang, Zhang, H. L., Liu, Y., Lu, B. C., Liu, X., Li, Q., and Cao, Y., Investigation of the association of two candidate genes (H-FABP and PSMC1) with growth and carcass traits in Qinchuan beef cattle from China, vol. 13, pp. 1876-1884, 2014.

Growth and carcass traits are economically important quality characteristics of beef cattle and are complex quantitative traits that are controlled by multiple genes. In this study, 2 candidate genes, H-FABP (encoding the heart fatty acid-binding protein) and PSMC1 (encoding the proteasome 26S subunit of ATPase 1) were investigated in Qinchuan beef cattle of China.

Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people

Y. H. Liu, Zhou, Y. W., Yang, J. A., Tu, Z. G., Ji, S. Y., Huang, Z. Y., and Zhou, Z. J., Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people, vol. 13, pp. 2619-2627, 2014.

This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chi­nese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han or­igin as controls. The SNP genotypes were performed by multiplex SNaP­shot technology. The HNRPUL1 gene rs11881940T and GATA2 gene rs3803T loci were highly correlated with CAD (P

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

L. Wang, Wang, Z. T., Hu, J. J., Fan, R., Zhou, J., and Zhong, J., Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis, vol. 13, pp. 2598-2610, 2014.

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inconsistent. Therefore, we conducted a meta-analysis to shed some light on this issue and explored the sources of the heterogeneity between studies.

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