Polymorphisms

Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma

H. F. Zhang, Yan, J. P., Zhuang, Y. S., and Han, G. Q., Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma, vol. 14, pp. 10524-10529, 2015.

The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not.

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