Polymorphisms

Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population

X. H. Wang, Wang, F. R., Tang, Y. F., Zou, H. Z., and Zhao, Y. Q., Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population, vol. 13, pp. 5048-5054, 2014.

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to be smokers and drinkers, have hepatitis B and C virus infections, and a family history of cancer.

Identification of complete linkage disequilibrium in the DSG4 gene and its association with wool length and crimp in Chinese indigenous sheep

Y. H. Ling, Xiang, H., Zhang, G., Ding, J. P., Zhang, Z. J., Zhang, Y. H., Han, J. L., Ma, Y. H., and Zhang, X. R., Identification of complete linkage disequilibrium in the DSG4 gene and its association with wool length and crimp in Chinese indigenous sheep, vol. 13, pp. 5617-5625, 2014.

The desmoglein 4 (DSG4) gene is a potential candidate in the search for genes that may affect wool traits, because of its function. This study aimed to screen for polymorphisms in partial exon 16 and 3ꞌUTR of the sheep desmoglein 4 DSG4 gene, and to test its possible association with wool length and crimp associated with fur. Overall, 326 sheep were scanned via single-strand conformational polymorphism assay, through three pairs of primers.

Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population

Y. Cao, Hu, J., Fang, Y., Chen, Q., and Li, H., Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population, vol. 13, pp. 7420-7427, 2014.

Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation.

Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population

M. F. Liu, Chen, W. Q., He, Y. Z., and Gu, Y. L., Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population, vol. 13, pp. 7184-7189, 2014.

MicroRNAs (miRNAs) are thought to play a role in cancer development. We conducted a case-control study to investigate the association between polymorphisms in miR-149C>T and hepatocellular carcinoma (HCC) risk. Duplex polymerase chain reaction with the confronting 2-pair primers were taken to genotype miR-149C>T. The association between genotype frequencies of miR-149C>T and risk of HCC was estimated as odds ratios (ORs) and 95% confidence intervals (95%CIs) using conditional regression analysis.

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Y. R. Zhang, Li, Y. K., Fu, C. Z., Wang, J. L., Wang, H. B., and Zan, L. S., Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle, vol. 13, pp. 8105-8117, 2014.

Beef cattle breeding programs focus on improving important economic traits, including growth rates, and meat quantity and quality. Molecular marker-assisted selection based on genetic variation represents a potential method for breeding genetically improved livestock with better economic traits. Smoothened (SMO) protein is a signal transducer that contributes to the regulation of both osteogenesis and adipogenesis through the hedgehog pathway.

Study of polymorphic variants of the serotonin 2A receptor gene (5-HT2A) and its possible effects on smoking habits of a population from northeastern Brazil

E. S. Ramos Neto, Mágulas, J. O., Sousa, J. J. S., Moura, A. C. M., Pinto, G. R., Yoshioka, F. K. N., Canalle, R., and Motta, F. J. N., Study of polymorphic variants of the serotonin 2A receptor gene (5-HT2A) and its possible effects on smoking habits of a population from northeastern Brazil, vol. 13, pp. 8268-8277, 2014.

Previous studies have revealed a genetic component, including genetic polymorphisms in the serotonergic pathway, particularly in the serotonin receptor gene (5-HT2A). The aim of this study was to investigate associations of the T102C (rs6313) and A-1438G (rs6311) polymorphisms with tobacco use in a population from northeastern Brazil. We evaluated these polymorphisms in 135 nonsmokers and 135 smokers using polymerase chain reaction-restricted fragment length polymorphism.

Functional polymorphisms of the glutamate receptor N-methyl D-aspartate 2A gene are associated with heroin addiction

H. J. Zhong, Huo, Z. H., Dang, J., Chen, J., Zhu, Y. S., and Liu, J. H., Functional polymorphisms of the glutamate receptor N-methyl D-aspartate 2A gene are associated with heroin addiction, vol. 13, pp. 8714-8721, 2014.

Heroin dependence is a debilitating psychiatric disorder with a complex inheritance mechanism. Genetic polymorphisms in functional regions of the glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene, which encodes the 2A subunit of the N-methyl D-aspartate (NMDA) receptor, may modulate the risk of heroin addiction.

Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site

J. Chen, Yuan, L., Duan, Y. Q., Jiang, J. Q., Zhang, R., Huang, Z. J., and Xiao, X. R., Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site, vol. 13, pp. 9718-9726, 2014.

Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of 767 patients with newly diagnosed gastric cancer and 775 controls were selected for this study.

Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

M. D. Bazzi, Nasr, F. A., Alanazi, M. S., Alamri, A., Turjoman, A. A., Moustafa, A. S., Alfadda, A. A., Pathan, A. A. K., and Parine, N. R., Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population, vol. 13, pp. 10194-10203, 2014.

Recent genome wide association studies identified many loci in several genes that have been consistently associated with type 2 diabetes mellitus in various ethnic populations. Among the genes that were most strongly associated with diabetes were fat mass- and obesity-associated, melanocortin 4 receptor, solute carrier family 30 member 8 (SLC30A8), and a member of the potassium voltage-gated channels.

The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy

Z. C. Wang, Shi, J. G., Chen, X. S., Xu, G. H., Li, L. J., and Jia, L. S., The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy, vol. 11, pp. 1238-1244, 2012.

We investigated a possible association of collagen IX tryptophan (Trp) alleles (Trp2 and Trp3) and smoking with cervical spondylotic myelopathy (CSM) in 172 Chinese patients and 176 age- and gender-matched controls. The smoking status was evaluated by smoking index (SI). The CSM cases had a significantly higher prevalence of Trp2 alleles (Trp2+) than controls (19.8 vs 6.2%, P = 0.002), but the prevalence of Trp3 alleles (Trp3+) was similar between the two groups (23.3 vs 21.6%, P = 0.713).

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