PPAR-δ

+294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease in normolipidemic Tunisians

I. Jguirim-Souissi, Jelassi, A., Hrira, Y., Najah, M., Slimani, A., Addad, F., Hassine, M., Hamda, K. B., Maatouk, F., Rouis, M., and Slimane, M. N., +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease in normolipidemic Tunisians, vol. 9, pp. 1326-1333, 2010.

Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we investigated a possible association of this polymorphism with plasma lipid and lipoprotein levels and with risk and outcome of CAD in a normolipidemic Tunisian population.

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