Primary open-angle glaucoma

Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis

Z. Wang, Li, M., Li, L., Sun, H., and Lin, X. Y., Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis, vol. 14, pp. 17262-17272, 2015.

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of Science, and PubMed. The extracted studies were selected for the meta-analysis based on the inclusion and exclusion criteria.

Familial primary open-angle glaucoma: a case report

K. Shi, Zhao, L., and Wang, C. Y., Familial primary open-angle glaucoma: a case report, vol. 13. pp. 3162-3164, 2014.

Primary open-angle glaucoma (POAG) is a disease that is often inherited, but the rules governing its inheritance are inconclusive. Herein, we report a case of POAG in a Chinese family. A 25-year-old female patient was referred to our department with progressive visual acuity decline in her left eye for the past 3 years. Ophthalmological examination supported our diagnosis of POAG in both eyes. We recorded the case history and clinical data of the proband and her family members and followed standard genetic study procedures.

Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma

N. B. Costa, Silva, C. T. X., Frare, A. B., Silva, R. E., and Moura, K. K. V. O., Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma, vol. 13, pp. 10382-10389, 2014.

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as primary open-angle glaucoma.

GSTM1 polymorphism in patients with primary open-angle glaucoma

A. M. Barbosa, Frare, A. B., Costa, N. B., Silva, R. E., and Moura, K. K. V. O., GSTM1 polymorphism in patients with primary open-angle glaucoma, vol. 11, pp. 3256-3262, 2012.

Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) are a group of drug-metabolizing enzymes of phase-II that act in the detoxification of xenobiotics and inactivate end-products formed as secondary metabolites during oxidative stress.

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