Prognosis

Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer

Y. P. Zhao, Wang, W., Wang, X. H., Xu, Y., Wang, Y., Dong, Z. F., and Zhang, J. J., Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer, vol. 14, pp. 18886-18894, 2015.

The Wnt inhibitor dickkopf-1 (DKK-1) has been shown to be closely correlated with tumor initiation and progression in various types of cancers. However, the serum level of DKK-1 in patients with papillary thyroid cancer (PTC) and its potential clinical significance is poorly understood. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the level of serum DKK-1 in patients with PTC (N = 132) and healthy controls (N = 40).

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