Progression

Vascular endothelial growth factor as an angiogenesis biomarker for the progression of autosomal dominant polycystic kidney disease

D. P. Martins, Souza, M. A., Baitello, M. E. Lopes, Nogueira, V., Oliveira, C. I. Ferreira, Pinhel, M. Ade Souza, Caldas, H. C., Filho, M. A., Souza, D. R. Silva, Martins, D. P., Souza, M. A., Baitello, M. E. Lopes, Nogueira, V., Oliveira, C. I. Ferreira, Pinhel, M. Ade Souza, Caldas, H. C., Filho, M. A., Souza, D. R. Silva, Martins, D. P., Souza, M. A., Baitello, M. E. Lopes, Nogueira, V., Oliveira, C. I. Ferreira, Pinhel, M. Ade Souza, Caldas, H. C., Filho, M. A., and Souza, D. R. Silva, Vascular endothelial growth factor as an angiogenesis biomarker for the progression of autosomal dominant polycystic kidney disease, vol. 15, p. -, 2016.

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary nephropathy characterized by abnormal growth of epithelial cells. Genetic factors, including the vascular endothelial growth factor (VEGF) gene, play an important role in its progression. The main aim of this study was to evaluate the influence of VEGF-C936T polymorphism in the development and progression of ADPKD. In total, 302 individuals were studied and divided into two groups: G1 (73 patients with ADPKD) and G2 (229 individuals without the disease).

XPG polymorphisms are associated with prognosis of advanced non-small cell lung cancer treated with platinum-based doublet chemotherapy

H. Z. Zou and Zhao, Y. Q., XPG polymorphisms are associated with prognosis of advanced non-small cell lung cancer treated with platinum-based doublet chemotherapy, vol. 14, pp. 500-506, 2015.

We conducted a cohort study to investigate whether 3 potential single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene could predict the survival of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet chemotherapy. We enrolled 262 patients with histologically confirmed NSCLC between November 2007 and December 2008 in this study. The 3 SNPs (rs2296147T>C, rs2094258C>T, and rs873601G>A) were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis.

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