Propofol

Bispectral index for monitoring anesthetic depth in patients with severe burns receiving target-controlled infusion of remifentanil and propofol

Z. G. Guo, Jia, X. P., Wang, X. Y., Li, P., Su, X. J., and Hao, J. H., “Bispectral index for monitoring anesthetic depth in patients with severe burns receiving target-controlled infusion of remifentanil and propofol”, vol. 14, pp. 7597-7604, 2015.

This study evaluated the feasibility and effectiveness of using the bispectral index (BIS) to monitor anesthetic depth in patients with severe burns receiving intravenous target-controlled infusion (TCI) of remifentanil and propofol. We randomly assigned 80 patients undergoing elective escharectomy (<1 week) to BIS (A) and control (B) groups. All patients received remifentanil and propofol as intravenous TCI anesthesia. Clinical data were recorded at different time points.

Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Dong, T. L., “Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression”, vol. 14, pp. 7529-7537, 2015.

Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion assay. Quantitative polymerase chain reaction (qPCR) was used to assess microRNA-133a (miR-133a) expression.

Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Yue, X. Q., “Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression”, vol. 14, pp. 8117-8124, 2015.

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel invasion assay. Real-time polymerase chain reaction (PCR) was used to assess microRNA (miR)-221 expression.

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children

X. Tian, Yang, Y. - H., Wei, H. - Y., Lao, J. - Q., Wang, H. - P., and Tian, Y. - Y., “Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children”, vol. 14, pp. 3687-3693, 2015.

This study explored the sedative and analgesic effects of fentanyl combined with propofol via an intrathecal chemotherapy injection for acute leukemia (acute lymphocytic leukemia or acute myelocytic leukemia) among children, to relieve pain and difficulty during intrathecal injection, improve treatment compliance, increase the success rate of single puncture, and reduce procedure failure, with the aim of developing a painless procedure for children with acute leukemia.

Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats

C. Wang, Liu, N., Li, R. - M., Zhang, Y., Shen, L., and Xiong, J. - Y., “Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats”, vol. 14, pp. 4740-4748, 2015.

The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis. The sepsis rat was used as a model. During glucocorticoid treatment, etomidate and propofol were applied alone or together at different time points. Survival curves, glucocorticoid receptor expression in the rat adrenal cortex, and inflammation levels were determined. The outcome of sepsis in rats was evaluated based on the combined utilization of propofol and etomidate.

Effects of maintaining intravenous infusion of remifentanil or propofol on anesthesia and palinesthesia during anesthesia and analepsia

X. Zhao, Jin, Y. W., Li, H. B., Wang, Z. G., Feng, H., and Feng, C., “Effects of maintaining intravenous infusion of remifentanil or propofol on anesthesia and palinesthesia during anesthesia and analepsia”, vol. 13, pp. 2865-2872, 2014.

When recovering from general anesthesia, upon removal of the endotracheal tube, patients may experience a high dynamic response in the circulatory system, along with choking and restlessness. This study was designed to study the effect of maintaining an intravenous infusion of remifentanil or propofol on the performance of general anesthesia, including on the cardiovascular response, choking and irritability at the end of general anesthesia. We treated 60 patients with combined inhalation and general anesthesia for lower esophageal cancer resection.

Comparative study of emergence agitation between isoflurane and propofol anesthesia in adults after closed reduction of distal radius fracture

G. Y. Liu, Chen, Z. Q., and Zhang, Z. W., “Comparative study of emergence agitation between isoflurane and propofol anesthesia in adults after closed reduction of distal radius fracture”, vol. 13, pp. 9285-9291, 2014.

Distal radius fracture is a common wound. It is reduced by surgery under anesthesia. Emergence agitation can often occur after anesthesia. It is associated with increased morbidity and hospital costs. However, there have been almost no reports in the medical literature on the occurrence of emergence agitation in adults. This study aimed to compare emergence agitation between isoflurane and propofol anesthesia in adults after closed reduction of distal radius fracture.

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