Prostate cancer

Expression and significance of S100P, CD147, and OCT4 in different prostate cancer tissue TNM stages

Q. Wang, Zhang, J. G., and Wang, W., “Expression and significance of S100P, CD147, and OCT4 in different prostate cancer tissue TNM stages”, vol. 14, pp. 6844-6851, 2015.

The aim of this project was to investigate the expression and significance of S100P, CD147, and OCT4 in prostate cancer tissue at different TNM stages. We enrolled 54 patients with prostate cancer, 40 with benign prostatic hyperplasia, and 20 subjects with normal prostates. S100P, CD147, and OCT4 were detected by immunohistochemistry. The positive rate of S100P detection was 18.52% in prostate cancer tissues, significantly lower than in normal and benign prostate hyperplasia tissues (P ˂ 0.05).

Biochip analysis of prostate cancer

M. Q. Fan, Wang, P. X., Feng, J. Y., Xiao, Y., and Huang, C. B., “Biochip analysis of prostate cancer”, vol. 13, pp. 152-159, 2014.

Microarray expression analysis was used to forecast the roles of differentially co-expressed genes (DCG) and DCG and links in the pathogenesis of prostate cancer. In addition, we demonstrate that the relationship between transcriptional factors (TFs) and their targets can be considered a key factor in determining the difference between primary and metastatic prostate cancer. Regulatory impact factors were adopted to calculate the impact of TF.

Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines

I. Kiliccioglu, Konac, E., Varol, N., Gurocak, S., and C. Bilen, Y., “Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines”, vol. 13, pp. 3721-3731, 2014.

Prostate cancer is one of the most common types of urological cancers. Despite the implementation of effective radiotherapy and chemotherapy methods, prostate cancer cells can still show resistance to treatment. In recent years, a combination of proteasome and histone deacetylase inhibitors has been used to treat various malignancies.

Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer

X. J. Zhang, Liu, P., and Zhu, F., “Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer”, vol. 13, pp. 4419-4424, 2014.

We aimed to investigate the association between genetic variants of the DNA repair genes XPG, CSB, XPC, CCNH, and MMS19L in the nucleotide excision repair (NER) pathway and risk of prostate cancer in a population in China. This study included 229 patients with newly diagnosed and histopathologically confirmed primary prostate cancer and 238 healthy controls. Genotyping of XPG, CSB, XPC, CCNH, and MMS19L were performed on a 384-well plate on the MassARRAY platform.

Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis

Y. Z. Xiang, Jiang, S. B., Zhao, J., Xiong, H., Cui, Z. L., Li, G. B., and Jin, X. B., “Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis”, vol. 13, pp. 6582-6592, 2014.

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the odds ratios (ORs) with corresponding 95% confidence intervals (CIs) of all currently available case-control studies located within PubMed and Embase databases up to December 2012.

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population

M. Chen, Zhou, Z. Y., Chen, J. G., Tong, N., Chen, S. Q., Yang, Y., Zhang, X. W., Jiang, H., Liu, N., Liu, J., Sha, G. Z., Zhu, W. D., Hua, L. X., Wang, Z. J., and Xu, B., “Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population”, vol. 13, pp. 10615-10621, 2014.

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were included in this study. miR-146a polymorphism was analyzed by PCR-RFLP. Its prognostic role in biochemical recurrence was assessed using Kaplan-Meier analysis and Cox regression model.

Evaluation of the effects of androgen receptor gene trinucleotide repeats and prostate-specific antigen gene polymorphisms on prostate cancer

D. Alptekin, Izmirli, M., Bayazit, Y., Luleyap, H. U., Yilmaz, M. B., Soyupak, B., Erkoc, M. A., and Tansug, Z., “Evaluation of the effects of androgen receptor gene trinucleotide repeats and prostate-specific antigen gene polymorphisms on prostate cancer”, vol. 11, pp. 1424-1432, 2012.

The number of trinucleotide repeats [CAG (coding for polyglutamine), GGC (coding for polyglycine)] in the first exon of the androgen receptor (AR) gene and prostate-specific antigen (PSA) gene androgen response element I A/G polymorphism are both related to prostate cancer prognosis. We investigated whether these genomic changes occur in the AR and PSA genes, which are usually found in individuals with prostate cancer, of Turkish patients and to find out their distribution in the population.

A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population

Q. Ren, Xu, B., Chen, S. Q., Yang, Y., Wang, C. Y., Wang, Y. D., Wang, X. H., Hua, L. X., and Chen, M., “A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population”, vol. 11, pp. 1349-1356, 2012.

Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate cancer patients and 273 control subjects were included in this case-control study. Genotypes were determined by PCR-RFLP.

Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer

H. - T. Zhang, Xu, Y., Zhang, Z. - H., and Li, L., “Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer”, vol. 11, pp. 1642-1650, 2012.

Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were considered in a meta-analysis, with 10,700 patients and 13,021 controls for rs20417 and 4087 patients and 3761 controls for rs689470.

Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population

J. M. Liu, Liu, J. N., Wei, M. T., He, Y. Z., Zhou, Y., Song, X. B., Ying, B. W., and Huang, J., “Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population”, vol. 12, pp. 820-829, 2013.

Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs1946518), in the IL-18 gene and prostate cancer occurrence and prognosis in Han Chinese.

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