Protein C

Cohn process influences the functional anticoagulant activity of human protein C

Z. K. Wang, Du, X., Wang, Y. M., Li, C. Q., Lin, F. Z., Cao, H. J., Ye, S. L., Hu, J. J., and Yuan, J., Cohn process influences the functional anticoagulant activity of human protein C, vol. 14, pp. 860-870, 2015.

Cohn fraction IV (CFIV) is a byproduct of a plasma fractionation process known as the Cohn process. It is an inexpensive source of protein C, retaining about 90% of protein C (PC) in human plasma. We investigated whether PC is affected during the Cohn process and evaluated correlations among coagulant activity, amidolytic activity and PC antigen during the Cohn process. CFIV was redissolved with citrate-buffered saline for 5 h at 4°C, and then centrifuged at 3500 g for 40 min at 4°C.

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