Psoriasis

Impact of BMMSCs from different sources on proliferation of CD34+ cells

R. F. Liu, Li, J. Q., Hou, R. X., Wang, R., and Zhang, K. M., Impact of BMMSCs from different sources on proliferation of CD34+ cells, vol. 14, pp. 474-482, 2015.

There are significant differences on the biological characteristics of bone marrow mesenchymal stem cells (BMMSCs), immunological response, and antigen-presenting functions between patients with psoriasis and normal subjects, but there are no significant differences in aborted fetuses. We examined the differences in BMMSCs between aborted fetuses and patients with psoriasis in this study. Bone marrow from normal subjects, aborted fetuses, and patients with psoriasis were obtained using a MidiMACS machine.

Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis

J. H. Qi, Shi, N., Chen, Y. J., and Nie, G., Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis, vol. 14, pp. 3869-3876, 2015.

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T polymorphism and psoriasis risk were retrieved from the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases.

Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway

J. Zhang and Ma, W. Y., Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway, vol. 13, pp. 9324-9335, 2014.

Decades of research have provided the data to confirm the hypothesis that there is bidirectional communication between the central nervous system and the immune system in psoriasis pathogenesis, but the contribution of the cutaneous neural system remains underexplored. In this study, we evaluated the molecular mechanisms by which nerve growth factor (NGF) regulates hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) production. The mRNA and protein levels of VEGF secretion from HaCaT cells by NGF were increased in a concentration-dependent manner.

Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro

C. Ronpirin and Tencomnao, T., Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro, vol. 11, pp. 412-420, 2012.

Although the precise causes of psoriasis remain to be elucidated, psoriasis has been known as a disorder in which factors in the immune system, enzymes and other biochemical substances that regulate skin cell division are functionally imbalanced, thereby resulting in rapid proliferation of keratinocytes and incomplete keratinization. The expression of candidate genes such as E2A and caspase-9, which have been recognized to play a critical role in cellular proliferation/differentiation and apoptosis, is of great interest.

Dithranol downregulates expression of Id1 mRNA in human keratinocytes in vitro

C. Ronpirin and Tencomnao, T., Dithranol downregulates expression of Id1 mRNA in human keratinocytes in vitro, vol. 11, pp. 3290-3297, 2012.

The precise causes of psoriasis, a chronic skin disorder characterized by hyperproliferation of keratinocytes and incomplete keratinization, are unclear. It is known that expression of helix-loop-helix transcription factor Id1, which functions as an inhibitor of differentiation, is upregulated in psoriatic skin. We investigated the effect of the antipsoriatic drug dithranol on mRNA and protein expression levels of Id1 in the HaCaT keratinocyte cell line. Cultured HaCaT cells were treated with 0-0.5 μg/mL dithranol for 30 min.

Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population

C. Ronpirin, Tencomnao, T., and Wongpiyabovorn, J., Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population, vol. 9, pp. 208-214, 2010.

Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls were included in our study. Genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism techniques.

An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population

T. Tencomnao and Wongpiyabovorn, J., An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population, vol. 9, pp. 2275-2282, 2010.

The serotonin transporter (5-HTT) is of great significance in the control of the serotonergic system, and its expression is known to be upregulated in psoriasis, a chronic or recurrent inflammatory skin disease. We investigated a possible association between the 5-HTT gene-linked polymorphic region (5-HTTLPR) and psoriasis in a Thai population. One hundred and fifty-six psoriatic patients and 156 unrelated healthy controls from Bangkok were genotyped using PCR. We found no overall differences in genotype distributions or allele frequencies between the two groups.

Up-regulation of Id1 in peripheral blood of psoriatic patients

C. Ronpirin, Achariyakul, M., Tencomnao, T., Wongpiyabovorn, J., and Chaicumpa, W., Up-regulation of Id1 in peripheral blood of psoriatic patients, vol. 9, pp. 2239-2247, 2010.

Although the precise causes of psoriasis are unclear, it is widely accepted that psoriasis is a disorder in which factors in the immune system, enzymes, and other biochemical substances that regulate skin cell division are impaired, leading to rapid proliferation of keratinocytes and incomplete keratinization. Expression of the helix-loop-helix transcription factor Id1 (inhibitor of differentiation/DNA binding), functioning as an inhibitor of differentiation, is known to increase in psoriatic skin.

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

D. Wu, Wu, Y., Liu, J. L., Wang, B., and Zhang, X. D., Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis, vol. 10, pp. 3109-3120, 2011.

Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI).

Association of -619C/T polymorphism in CDSN gene and psoriasis risk: a meta-analysis

Y. Wu, Wang, B., Liu, J. L., Gao, X. H., Chen, H. D., and Li, Y. H., Association of -619C/T polymorphism in CDSN gene and psoriasis risk: a meta-analysis, vol. 10, pp. 3632-3640, 2011.

Previous studies investigating the association between corneodesmosin (CDSN) polymorphisms and psoriasis risk have provided inconsistent results. The aim of our study was to clarify the effects of CDSN -619C/T polymorphism on psoriasis risk by conducting a meta-analysis. We conducted searches of the published literature in Pubmed and Embase databases up to October 2010. Six studies with a total of 842 psoriasis cases and 981 healthy controls were retrieved. Statistical analysis was performed with the programs Review Manager (version 5.0.24) and Stata (version 9.2).

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