Pulmonary fibrosis

Atomized paclitaxel liposome inhalation treatment of bleomycin-induced pulmonary fibrosis in rats

Y. Zhou, Zhu, W. P., Cai, X. J., Chen, M., Zhou, Y., Zhu, W. P., Cai, X. J., Chen, M., Zhou, Y., Zhu, W. P., Cai, X. J., and Chen, M., Atomized paclitaxel liposome inhalation treatment of bleomycin-induced pulmonary fibrosis in rats, vol. 15, p. -, 2016.

We sought to determine the efficacy of atomized paclitaxel liposome inhalation treatment of pulmonary fibrosis in a bleomycin-induced rat model. Forty male Sprague-Dawley rats were randomly divided into four groups: healthy control, pulmonary fibrosis without treatment, paclitaxel liposome inhalation-treated, and intravenous paclitaxel liposome-treated. Fibrosis was induced by bleomycin injection. A total of 20 mg/kg paclitaxel liposome was administered by inhalation every other day for a total of 10 doses.

Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis

G. - X. Hu, Yao, S. - T., Zeng, L. - H., Peng, Y. - Z., and Zheng, J., Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis, vol. 14, pp. 4625-4632, 2015.

The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5. We used hematoxylin eosin staining to observe the degree of pulmonary fibrosis in rats; Masson staining, reverse transcription polymerase chain reaction, and immunohistochemistry were used to observe the expression of collagen, MMP-1, and TIMP-1, and type I collagen.

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