Pulmonary tuberculosis

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

G. L. Shi, Yang, L., Sun, Y., Yin, Y. J., and Song, C. X., “MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis”, vol. 14, pp. 4035-4040, 2015.

Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and Korean populations.

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

F. M. Feng, Liu, X. X., Sun, Y. H., Zhang, P., Sun, S. F., Zhang, B., Wang, X. T., and Lu, L. J., “Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population”, vol. 13, pp. 7766-7772, 2014.

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.

Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han

C. Lu, Shen, Y. - J., Deng, Y. - F., Wang, C. - Y., Fan, G., Liu, Y. - Q., Zhao, S. - M., Zhang, B. - C., Zhao, Y. - R., Wang, Z. - E., Zhang, C. - Z., and Lu, Z. - M., “Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han”, vol. 11, pp. 1370-1378, 2012.

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis patients and 110 healthy controls using sequence-specific primer PCR analysis of genomic DNA.

Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients

G. L. Shi, Hu, X. L., Yang, L., Rong, C. L., Guo, Y. L., and Song, C. X., “Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients”, vol. 10, pp. 1331-1336, 2011.

Human leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4+ T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases.

Subscribe to Pulmonary tuberculosis