Rab23

Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma

Z. Z. Cai, Xu, L. B., Cai, J. L., Wang, J. S., Zhou, B., and Hu, H., Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma, vol. 14, pp. 2707-2715, 2015.

Pancreatic ductal adenocarcinoma (PDAC) is charac­terized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pan­creatic tissue samples (P = 0.0073), respectively. There were signifi­cant correlations between Rab23 expression and unfavorable variables, including cancer differentiation level (P = 0.0089), lymph nodal (P = 0.0099), and distant metastases (P = 0.0173).

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