Radiotherapy

Efficacy of dendritic cell-cytokine-induced killer immunotherapy plus intensity-modulated radiation therapy in treating elderly patients with esophageal carcinoma

L. Yan, Wu, M., Ba, N., Wang, L. J., Zhang, H. Q., Shi, G. Y., Zhang, Z. S., and Wang, X. J., Efficacy of dendritic cell-cytokine-induced killer immunotherapy plus intensity-modulated radiation therapy in treating elderly patients with esophageal carcinoma, vol. 14, pp. 898-905, 2015.

We investigated the clinical efficacy of adoptive cytokine-induced killer (CIK) cell and dendritic cell (DC) therapy plus intensity-modulated radiation therapy (IMRT) for treating elderly patients with esophageal carcinoma (EC). In total, 68 elderly patients with EC were randomized to receive IMRT plus DC-CIK immunotherapy (study group, N = 34) or IMRT only (control group, N = 34). Clinical efficacy, immune function, toxicity and side effects, and life quality were evaluated after treatment. The efficacy rate was significantly higher in the study group than in the control group.

Magnetic resonance spectroscopic imaging of brain injury after nasopharyngeal cancer radiation in early delayed reaction

W. - S. Chen, Li, J. - J., Zhang, J. - H., Hong, L., Xing, Z. - B., Wang, F., and Li, C. - Q., Magnetic resonance spectroscopic imaging of brain injury after nasopharyngeal cancer radiation in early delayed reaction, vol. 13, pp. 6848-6854, 2014.

This study aimed to investigate the value of magnetic resonance spectroscopy (MRS) imaging in assessing nasopharyngeal carcinoma radiotherapy during the early delayed reaction period. Eighty cases of nasopharyngeal cancer treated with radiotherapy within the same period underwent MRS imaging before or after radiotherapy. Of the 80 cases, 47 underwent MRS imaging on the 3rd, 4th, 6th, and 12th months after radiotherapy. The trends of the primary metabolite concentration at different time points were monitored and compared with the corresponding data after radiotherapy.

Effect of radiotherapy on the treatment of patients with extensive stage small cell lung cancer

C. Wu, Wang, T., Wang, J., Qu, B., Wang, H., and Hu, Y., Effect of radiotherapy on the treatment of patients with extensive stage small cell lung cancer, vol. 13, pp. 8577-8585, 2014.

Small cell lung cancer (SCLC) is an aggressive disease, in which more than 80% of patients present distant metastases at the time of first diagnosis. Chemotherapy is considered as the main treatment of extensive disease of SCLC (ED-SCLC), while the role of radiotherapy in the treatment of ED-SCLC is controversial. A case-control study was undertaken of patients diagnosed as ED-SCLC between 2004 and 2010.

Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro

I. V. Almeida, Düsman, E., Heck, M. C., Pamphile, J. A., Lopes, N. B., Tonin, L. T. D., and Vicentini, V. E. P., Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro, vol. 12, pp. 6402-6413, 2013.

The radioisotope iodine-131 [131I] can damage DNA. One way to prevent this is to increase the amount of antioxidants via dietary consumption. The goal of this study was to evaluate the radioprotective effect of fresh acerola pulp and synthetic beta-carotene in Rattus norvegicus hepatoma cells (HTC) in response to [131I] exposure in vitro. Cellular DNA damage was subsequently assessed using a cytokinesis block micronucleus assay.

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