Radiotherapy

miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4

Y. H. Zhang, Wang, Q. Q., Li, H., Ye, T., Gao, F., Liu, Y. C., Zhang, Y. H., Wang, Q. Q., Li, H., Ye, T., Gao, F., and Liu, Y. C., miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4, vol. 15, p. -, 2016.

Radiotherapy is one of the most important treatments for esophageal cancer, but radioresistance remains a major challenge. Previous studies have shown that microRNAs (miRNAs or miRs) are involved in human cancers. miR-124 has been widely reported in various cancers and it is intimately involved in proliferation, cell cycle regulation, apoptosis, migration, and invasion of cancer cells. The aim of this study was to explore the relationship between the miR-124/cyclin-dependent kinase 4 (CDK4) axis and the radiosensitivity of esophageal cancer cells.

Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism

E. Stur, Agostini, L. P., Garcia, F. M., Peterle, G. T., Maia, L. L., Mendes, S. O., Anders, Q. S., Reis, R. S., Santos, J. A., Ventorim, D. P., Carvalho, M. B., Tajara, E. H., Santos, M., Paula, F., Silva-Conforti, A. M. A., and Louro, I. D., Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism, vol. 14, pp. 12446-12454, 2015.

The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). Peripheral blood DNA was extracted from 311 patients and analyzed by PCR-RFLP.

MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma

Q. S. Anders, Stur, E., Agostini, L. P., Garcia, F. M., Reis, R. S., Santos, J. A., Mendes, S. O., Maia, L. L., Peterle, G. T., Stange, V., Carvalho, M. B., Tajara, E. H., Santos, M., Silva-Conforti, A. M. A., and Louro, I. D., MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma, vol. 14, pp. 13105-13109, 2015.

The C677T and A1298C polymorphisms in methylene­tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous cell carcinoma (HNSCC) may respond differently to radiotherapy treatments, based on genetic polymor­phisms. Therefore, this study sought to understand the role of these polymorphisms in HNSCC patient radiotherapy response.

Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice

Z. T. Shen, Wu, X. H., Wang, L., Li, B., and Zhu, X. X., Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice, vol. 14, pp. 15587-15596, 2015.

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays, and inhibition rates were compared to evaluate the gemcitabine enhancement factor.

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