RANKL

MicroRNA-338-3p inhibits glucocorticoid-induced osteoclast formation through RANKL targeting

X. H. Zhang, Geng, G. L., Su, B., Liang, C. P., Wang, F., Bao, J. C., Zhang, X. H., Geng, G. L., Su, B., Liang, C. P., Wang, F., and Bao, J. C., “MicroRNA-338-3p inhibits glucocorticoid-induced osteoclast formation through RANKL targeting”, vol. 15, p. -, 2016.

The differentiation deficiencies of osteoclast precursors (pre-OCs) may contribute to osteoporosis. Research on osteoporosis has recently focused on microRNAs (miRNAs) that play crucial roles in pre-OC differentiation. In the current study, we aimed to analyze the expression and function of the glucocorticoid (GC)-associated miRNA-338-3p (miR-338-3p) in osteoclast formation. We found that dexamethasone induced osteoclast differentiation and inhibited miR-338-3p expression.

Expression of OPG, RANKL, and RUNX2 in rabbit periodontium under orthodontic force

B. Li, Zhang, Y. H., Wang, L. X., Li, X., and Zhang, X. D., “Expression of OPG, RANKL, and RUNX2 in rabbit periodontium under orthodontic force”, vol. 14, pp. 19382-19388, 2015.

This study aims to investigate the expression changes of RANKL, RUNX2, and OPG in rabbit periodontal tissues under orthodontic force and explore its effect on the remodeling of periodontal tissues. A total of 16 specific pathogen-free rabbits were used in this study. The maxillary appliance was worn on the right (experimental) side, and the appliance-free left side was used as the control. Rabbits were sacrificed after 3, 5, 7, and 14 days of treatment.

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