Rat

Expression and distribution of SP and its NK1 receptor in the brain-gut axis in neonatal maternally separated rat model with visceral hypersensitivity

W. Teng, Chen, H., Guo, F., Du, X., Fu, X., Fang, Y., Zhang, H., Fang, M., Ding, M., Teng, W., Chen, H., Guo, F., Du, X., Fu, X., Fang, Y., Zhang, H., Fang, M., and Ding, M., Expression and distribution of SP and its NK1 receptor in the brain-gut axis in neonatal maternally separated rat model with visceral hypersensitivity, vol. 15, p. -, 2016.

Neurokinin-1 receptor (NK1R) is a high affinity Substance P (SP) receptor and plays a key role in visceral hypersensitivity in irritable bowel syndrome (IBS). Early life stress is a significant risk factor in IBS. The aim of the present study was to investigate the influence of neonatal maternal separation on the expression and distribution of SP and its receptor along the brain-gut axis in a neonatal maternally separated rat model with visceral hypersensitivity.

Subscribe to Rat