Rat

Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis

L. - D. Liu, Wu, X. - Y., Tao, B. - D., Wang, N., Zhang, J., Liu, L. - D., Wu, X. - Y., Tao, B. - D., Wang, N., Zhang, J., Liu, L. - D., Wu, X. - Y., Tao, B. - D., Wang, N., and Zhang, J., “Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis”, vol. 15, p. -, 2016.

This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung injury group [lipopolysaccharide (LPS) injection (ip, 15 mg/kg), air drawing; LA], and acute lung injury combined with hydrogen drawing group [LPS injection (ip, 15 mg/kg), 2% hydrogen drawing; LH].

Effects of MK-801 concentration on cell proliferation in rats with focal cerebral ischemia-reperfusion

Y. K. Gui, Su, L. L., Niu, X. L., Zeng, P., Fang, R. R., Lv, H. X., and Zhang, P., “Effects of MK-801 concentration on cell proliferation in rats with focal cerebral ischemia-reperfusion”, vol. 14, pp. 12841-12847, 2015.

We explored the relationship between MK-801 concentration and neural stem cell proliferation in rats with focal cerebral ischemia-reperfusion (FCIR). A total of 60 male Sprague Dawley rats were randomized into control (six rats), sham-operation (six rats), operation (12 rats), and MK-801 groups. The MK-801 group comprised 36 rats that were subjected to different doses of MK-801 (0.2, 0.4, 0.6, 0.8, 1.0, and 1.2 mg/kg).

Fructus polygoni orentalis extract inhibited liver regeneration and proliferation of bone marrow cells of rat after partial hepatectomy

J. Y. Yang, Wang, J. S., and Liu, H. B., “Fructus polygoni orentalis extract inhibited liver regeneration and proliferation of bone marrow cells of rat after partial hepatectomy”, vol. 14, pp. 7671-7679, 2015.

To study the effect of fructus polygoni orentalis extract (EFPO) on liver regeneration and proliferation of bone marrow cells on rat model of partial hepatectomy, EFPO was extracted, and 60 adult male Wistar rats were divided randomly into 6 experimental groups. Rats were treated with intergastric administration (ig) with EFPO daily. All rats were euthanized 7 days after administration, and the livers and bone marrow cells were collected. The levels of taxifolin and quercetin in EFPO were 1.238 and 0.381 mg/g, respectively.

Expression of N-cadherin in myocardial tissues during the development of a rat heart

L. M. Mu, Wang, W. F., Zheng, H., Guo, Z. K., and Zhang, G. M., “Expression of N-cadherin in myocardial tissues during the development of a rat heart”, vol. 14, pp. 9882-9889, 2015.

We investigated the expression and distribution of N-cadherin during the development of a rat heart. Immunohistochemistry (IHC) was performed to detect the expression and distribution of N-cadherin in the myocardial tissues of rats at embryonic day 18 (E18d), postnatal day 5 (P5d), postnatal day 19 (P19d), postnatal day 40 (P40d), and postnatal year 1 (P1y). Reverse transcription polymerase chain reaction was used to determine mRNA expression levels of N-cadherin in the myocardial tissues at E18d, P5d, P19d, P40d, and P1y.

Effect of chronic hypoxia on penile erectile function in rats

D. P. Yu, Liu, X. H., and Wei, A. Y., “Effect of chronic hypoxia on penile erectile function in rats”, vol. 14, pp. 10482-10489, 2015.

We examined the relationship between chronic hypoxia and erectile dysfunction in rat and its possible pathogenic mechanism. Forty-eight white male adult Sprague-Dawley rats were randomly divided into a test group and a control group. In accordance with the experimental time (2, 6, and 10 weeks), each group was divided into 3 subgroups, with 8 rats in each subgroup. Rats in the test group were fed in an airtight hypoxia cabin, while rats in the control group were maintained in a normal environment, with other conditions kept the same.

Establishment and characterization of a rat model of hyperphosphatemia

C. Zhang, Shao, Y., Zhu, Q. - G., Li, Y., Jin, C. - L., Wang, H. - P., Zhou, L., Yu, C., Zhao, Y. K., Yuan, G. J., Hu, X. - P., Zhang, L., and Wang, H., “Establishment and characterization of a rat model of hyperphosphatemia”, vol. 14, pp. 11089-11098, 2015.

We established a rat model of hyperphosphatemia and investigated the systemic effects of high phosphorus (P). Sprague Dawley rats were randomly divided into high (HP), low (LP), and normal (NP) P groups (N = 12 each), which received injections of fructose diphosphate sodium, or were fed self-manufactured low phosphorus or normal diets, respectively. In each group, 4 rats were sacrificed at the first, third, and sixth week to detect the serum (Scr) and urinary creatinine and P, and calcium (Ca) levels.

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