Rat liver regeneration

Branches of the NF-κB signaling pathway regulate proliferation of oval cells in rat liver regeneration

W. M. Zhao, Qin, Y. L., Niu, Z. P., Chang, C. F., Yang, J., Li, M. H., Zhou, Y., Xu, C. S., Zhao, W. M., Qin, Y. L., Niu, Z. P., Chang, C. F., Yang, J., Li, M. H., Zhou, Y., Xu, C. S., Zhao, W. M., Qin, Y. L., Niu, Z. P., Chang, C. F., Yang, J., Li, M. H., Zhou, Y., and Xu, C. S., Branches of the NF-κB signaling pathway regulate proliferation of oval cells in rat liver regeneration, vol. 15, p. -, 2016.

The NF-kB (nuclear factor kB) pathway is involved in the proliferation of many cell types. To explore the mechanism of the NF-kB signaling pathway underlying the oval cell proliferation during rat liver regeneration, the Rat Genome 230 2.0 Array was used to detect expression changes of NF-kB signaling pathway-related genes in oval cells. The results revealed that the expression levels of many genes in the NF-kB pathway were significantly changed. This included 48 known genes and 16 homologous genes, as well as 370 genes and 85 homologous genes related to cell proliferation.

Branches of NF-κb signaling pathway regulate hepatocyte proliferation in rat liver regeneration

C. F. Chang, Zhao, W. M., Mei, J. X., Zhou, Y., Pan, C. Y., Xu, T. T., and Xu, C. S., Branches of NF-κb signaling pathway regulate hepatocyte proliferation in rat liver regeneration, vol. 14, pp. 7643-7654, 2015.

Previous studies have demonstrated that the nuclear factor κB (NF-κB) pathway is involved in promoting cell proliferation. To further explore the regulatory branches and their sequence in the NF-κB pathway in the promotion of hepatocyte proliferation at the transcriptional level during rat liver regeneration, Rat Genome 230 2.0 array was used to detect the expression changes of the isolated hepatocytes.

Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells

C. F. Chang, Yang, J., Zhao, W. M., Li, Y., Guo, P. J., Li, M. H., Zhou, Y., and Xu, C. S., Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells, vol. 14, pp. 3409-3420, 2015.

We examined the gene expression profiles of the 5-hydroxytryptamine signaling pathway in the regenerating liver and 8 types of liver cells during rat liver regeneration, and explored expression differences in 5-hydroxytryptamine signaling pathway genes at the level of tissues and cells, as well as the role of the pathway on liver regeneration. Eight types of rat regenerating liver cells were isolated using Percoll density-gradient centrifugation and immunomagnetic bead methods.

Three branches of phospholipase C signaling pathway promote hepatocyte growth in rat liver regeneration

G. G. Xu, Geng, Z., Zhou, X. C., He, Y. G., He, T. T., Mei, J. X., Yang, Y. J., Liu, Y. Q., and Xu, C. S., Three branches of phospholipase C signaling pathway promote hepatocyte growth in rat liver regeneration, vol. 14, pp. 5710-5723, 2015.

In general, the phospholipase C (PLC) signaling pathway is involved in many physiological activities, including cell growth. However, little is known regarding how the PLC signaling pathway participates in regulating hepatocyte (HC) growth during liver regeneration (LR). To further explore the influence of the PLC signaling pathway on HCs at the cellular level, HCs of high purity and vitality were isolated using Percoll density-gradient centrifugation after partial hepatectomy.

Differential gene expression and functional analysis of pit cells from regenerating rat liver

C. S. Xu, Chen, X. G., Chang, C. F., Wang, G. P., Wang, W. B., Zhang, L. X., Zhu, Q. S., and Wang, L., Differential gene expression and functional analysis of pit cells from regenerating rat liver, vol. 10, pp. 678-692, 2011.

Hepatic pit cells are a population of large granular lymphocytes that substantially contribute to hepatic immunity. Studies have proven that pit cells have a role in liver regeneration, but the details of the relationship between pit cells and liver regeneration is not clear at present.

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