Real-time PCR

Gene expression changes in chicken NLRC5 signal pathway associated with in vitro avian leukosis virus subgroup J infection

L. L. Qiu, Xu, L., Guo, X. M., Li, Z. T., Wan, F., Liu, X. P., Chen, G. H., Chang, G. B., Qiu, L. L., Xu, L., Guo, X. M., Li, Z. T., Wan, F., Liu, X. P., Chen, G. H., Chang, G. B., Qiu, L. L., Xu, L., Guo, X. M., Li, Z. T., Wan, F., Liu, X. P., Chen, G. H., and Chang, G. B., Gene expression changes in chicken NLRC5 signal pathway associated with in vitro avian leukosis virus subgroup J infection, vol. 15, p. -, 2016.

Nucleotide-binding oligomerization domain-like receptors (NLRs) play a key role in the innate immune response as pattern-recognition receptors. However, the role of NLRC5, which is a member of the NLR family, in NF-κB activation and MHC-I expression remains debatable. Infection with the J group avian leukosis virus (ALV-J) can result in immunosuppression and a subsequent increase in susceptibility to secondary infection. This results in huge economic losses to the poultry industry worldwide.

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