Refractory anemia with excess blasts

Global gene expression profile in myelodysplastic syndromes using SAGE

C. F. Mendiburu, Silva, Jr, W. A., Ricci, Jr., O., Bonini-Domingos, C. R., and Fett-Conte, A. C., Global gene expression profile in myelodysplastic syndromes using SAGE, vol. 7, pp. 1245-1250, 2008.

The molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a partial transcriptome of RAEB bone marrow derived from 56,694 sequenced tags that provides information about expressed gene products.

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