Resveratrol

Tristetraprolin: a novel mediator of the anticancer properties of resveratrol

C. Li, Tang, C., He, G., Li, C., Tang, C., and He, G., Tristetraprolin: a novel mediator of the anticancer properties of resveratrol, vol. 15, p. -, 2016.

Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associated with the abnormal expression of multiple cytokines. Tristetraprolin (TTP), an mRNA-binding protein, is one of the key proteins that participate in regulating cytokine expression.

Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells

J. P. Li, Ma, Q., Chen, C. M., Li, J. P., Ma, Q., Chen, C. M., Li, J. P., Ma, Q., and Chen, C. M., Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells, vol. 15, p. -, 2016.

This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 activity and a decrease in Bcl-2, which caused an increase in membrane permeability, and the opening of mitochondrial permeability transition pores and mitochondrial depolarization.

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