Rheumatoid arthritis

Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran

M. Hashemi, Moazeni-Roodi, A. K., Fazaeli, A., Sandoughi, M., Bardestani, G. R., Kordi-Tamandani, D. M., and Ghavami, S., “Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran”, vol. 9, pp. 333-339, 2010.

Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q192R polymorphism in 88 rheumatoid arthritis patients and 78 healthy subjects was determined using tetra amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and PCR-restriction fragment length polymorphism (RFLP) methods.

The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis

M. Hashemi, Moazeni-Roodi, A. K., Fazaeli, A., Sandoughi, M., Taheri, M., Bardestani, G. R., Zakeri, Z., Kordi-Tamandani, D. M., and Ghavami, S., “The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis”, vol. 9, pp. 1735-1741, 2010.

araoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subjects, using the tetra-amplification refractory mutation system-PCR method.

No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population

L. P. Sun, Ma, X. L., Liu, H. X., Wang, Y. S., and Li, X. F., “No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population”, vol. 9, pp. 1518-1524, 2010.

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a Chinese Han population.

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

L. O. Cavalcante, Melo, M. R., Dinis, V. G., Castro, R. B., Souza, B. D. B., and Longui, C. A., “Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients”, vol. 9, pp. 2300-2310, 2010.

We measured NF-κB, IKK, c-Fos, and GRαmRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients who were not on glucocorticoids during the previous four months and on blood samples from 20 healthy individuals.

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