Rifampicin

Rifampicin resistance among multi-resistant MRSA clinical isolates from Chennai, India, and their molecular characterization

K. Murugan, Kavitha, K., and Al-Sohaibani, S., Rifampicin resistance among multi-resistant MRSA clinical isolates from Chennai, India, and their molecular characterization, vol. 14, pp. 2716-2725, 2015.

High-level methicillin-resistant Staphylococcus aureus (MRSA) isolates show rapid evolution of rifampicin resistance, forcing reliance upon expensive and often inferior antibiotics to manage these infections. Accordingly, this study was conducted to: 1) evaluate the level of multidrug resistance among hospital-associated MRSA isolates from Chennai, India; 2) determine their rifampicin resistance and molecular characterization; and 3) analyze the identified rpoB gene mutations for predominant high-level rifampicin resistance-associated nucleotide changes.

Effects of rifampicin on osteogenic differentiation and proliferation of human mesenchymal stem cells in the bone marrow

Z. Zhang, Wang, X., Luo, F., Yang, H., Hou, T., Zhou, Q., Dai, F., He, Q., and Xu, J., Effects of rifampicin on osteogenic differentiation and proliferation of human mesenchymal stem cells in the bone marrow, vol. 13, pp. 6398-6410, 2014.

This study was designed to investigate the effect of different concentrations of rifampicin on osteogenic differentiation and proliferation of mesenchymal stem cells (MSCs) in human bone marrow. Rifampicin treatment at 0, 4, 8, 16, 32, 64, and 128 mg/mL was applied throughout the whole process, from stromal cells purified from human bone marrow to differentiated bone cells. The effect of rifampicin on MSC proliferation was determined using the MTT assay.

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