Rs1800587

Association of IL-1α gene polymorphism with susceptibility to type 1 diabetes in Chinese children

X. Zhou, Ca, J. G., Peng, H., Wang, J. L., Li, G. M., Zhou, X., Ca, J. G., Peng, H., Wang, J. L., and Li, G. M., Association of IL-1α gene polymorphism with susceptibility to type 1 diabetes in Chinese children, vol. 15, p. -, 2016.

The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes (T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 rs1800587 gene polymorphism to susceptibility to T1D in Chinese children. This case-control study included 332 Chinese children with T1D and 332 healthy controls. Identification of genetic variants of rs1800587 in the IL-1α gene was performed by polymerase chain reaction amplification. The IL-1α rs1800587 polymorphism demonstrated a significant association with T1D risk.

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