Safety

Safety of recombinant human granulocyte-macrophage colony-stimulating factor in healing pediatric severe burns

Y. F. Chi, Chai, J. K., Luo, H. M., Zhang, Q. X., and Feng, R., Safety of recombinant human granulocyte-macrophage colony-stimulating factor in healing pediatric severe burns, vol. 14, pp. 2735-2741, 2015.

We explored the safety of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for healing burns in children. Subjects were randomly assigned to two groups: the experimental group received external rhGM-CSF gel, and the control group received rhGM-CSF gel matrix components, applied to the burn surface. Neither group was given any other drugs that promote wound healing. Each day we recorded the pulse, body temperature, and respiration status in the two groups.

Effectiveness of olfactory ensheathing cell transplantation for treatment of spinal cord injury

Y. J. Rao, Zhu, W. X., Du, Z. Q., Jia, C. X., Du, T. X., Zhao, Q. A., Cao, X. Y., and Wang, Y. J., Effectiveness of olfactory ensheathing cell transplantation for treatment of spinal cord injury, vol. 13, pp. 4124-4129, 2014.

The aim of this study was to determine the effectiveness and safety of transplantation of olfactory ensheathing cells for functional repair of the spinal cord. An olfactory bulb was obtained from a 4- to 5-month-old aborted fetus, and it was digested into single olfactory ensheathing cells and then cultured and purified for 1 to 2 weeks. Under general anesthesia, these single-cell suspensions of olfactory ensheathing cells were injected into the corresponding spinal injury site with 0.45-mm-diameter injections.

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