Sepsis

Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats

C. Wang, Liu, N., Li, R. - M., Zhang, Y., Shen, L., and Xiong, J. - Y., “Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats”, vol. 14, pp. 4740-4748, 2015.

The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis. The sepsis rat was used as a model. During glucocorticoid treatment, etomidate and propofol were applied alone or together at different time points. Survival curves, glucocorticoid receptor expression in the rat adrenal cortex, and inflammation levels were determined. The outcome of sepsis in rats was evaluated based on the combined utilization of propofol and etomidate.

Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique

J. P. Liu, Wang, X. W., and Qie, L. P., “Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique”, vol. 14, pp. 5685-5693, 2015.

We analyzed disease severity, inflammation markers, and dynamic changes in cartilage glycoprotein 39 (YKL-40) and C-reactive protein (CRP) levels in children with sepsis before and after treatment with continuous blood purification (CBP). Study participants were 30 children with severe sepsis who were cured from the disease (experimental group) in the Children’s Serious Disease Center of In­ner Mongolia People’s Hospital between June 2012 and October 2013. Symptomatic CBP treatment was performed after disease severity scor­ing.

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Y. Yu, Wang, W. N., Han, H. Z., Xie, K. L., Wang, G. L., and Yu, Y. H., “Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin”, vol. 14, pp. 6202-6212, 2015.

We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated hydrogen-rich medium.

Screening of differentially expressed genes between multiple trauma patients with and without sepsis

S. C. Ji, Pan, Y. T., Lu, Q. Y., Sun, Z. Y., and Liu, Y. Z., “Screening of differentially expressed genes between multiple trauma patients with and without sepsis”, vol. 13, pp. 1855-1864, 2014.

The purpose of this study was to identify critical genes associated with septic multiple trauma by comparing peripheral whole blood samples from multiple trauma patients with and without sepsis. A microarray data set was downloaded from the Gene Expression Omnibus (GEO) database. This data set included 70 samples, 36 from multiple trauma patients with sepsis and 34 from multiple trauma patients without sepsis (as a control set). The data were preprocessed, and differentially expressed genes (DEGs) were then screened for using packages of the R language.

Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats

J. Xiong, Xu, L., Qu, W. M., Li, Z. L., Shang, Z. H., Li, Y. H., Yang, S. H., and Yang, Z. H., “Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats”, vol. 13, pp. 8209-8219, 2014.

Sepsis is a complex inflammatory response to infection, associating with dramatic metabolic disorders. Although the mechanisms of immune response during sepsis have been largely clarified, current studies rarely pay attention to the disordered protein metabolism in sepsis. In this study, L6 rat skeletal muscle cells treated with serum from septic rats were used as an in vitro model for sepsis-like condition in skeletal muscle.

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