Short hairpin RNA

Silencing FKBP38 gene by siRNA induces activation of mTOR signaling in goat fetal fibroblasts

Y. T. Fu, Zheng, X., He, Q., Jia, X. Y., Guo, Z. X., Yao, R. Y., Wang, Y. F., and Wang, Z. G., Silencing FKBP38 gene by siRNA induces activation of mTOR signaling in goat fetal fibroblasts, vol. 14, pp. 9675-9682, 2015.

FKBP38 (also known as FKBP8) is a unique member of the FK506-binding protein (FKBP) family, and its role is controversial because it acts as an upstream regulator of the mTOR signaling pathway, which controls cell growth, proliferation, and differentiation. This study aimed to explore the role of FKBP38 in the activation of mTOR signaling in Cashmere goat (Capra hircus) fetal fibroblasts. To construct a Cashmere goat FKBP38 siRNA eukaryotic expression vector that targets FKBP38 mRNA, we designed shRNA based on the gene sequence deposited in GenBank (accession No.

Subscribe to Short hairpin RNA