Single nucleotide polymorphism

Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

G. L. Hong, Chen, X. Z., Liu, Y., Liu, Y. H., Fu, X., Lin, S. B., and Zhu, Q., Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population, vol. 12, pp. 6220-6227, 2013.

Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of hypertension in a Chinese Han population. A hospital-based case-control study in a Chinese Han population was carried out, including 500 hypertension patients and 506 healthy controls.

Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population

C. Ronpirin, Tencomnao, T., and Wongpiyabovorn, J., Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population, vol. 9, pp. 208-214, 2010.

Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls were included in our study. Genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism techniques.

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