Absence of SH2B3 mutation in nonobese diabetic mice
“Absence of SH2B3 mutation in nonobese diabetic mice”, vol. 11, pp. 1266-1271, 2012.
, Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing β-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and 12q24 arises from SNP rs3184504; rs3184504 is a nonsynonymous SNP in exon 3 of SH2B3 (also known as LNK).