Single nucleotide polymorphism

Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population

C. - P. Zhou, Pan, H. - Z., Li, F. - X., Hu, N. - Y., Li, M., and Yang, X. - X., “Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population”, vol. 13, pp. 3673-3680, 2014.

Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the risk for GC in a southern Chinese population. All SNPs were genotyped in 249 individuals with GC and 292 healthy population-matched subjects using the Sequenom MassArray iPLEX System.

Association of BRCA2 variants with cardiovascular disease in Saudi Arabia

M. Alanazi, Reddy, N. P., Shaik, J. P., Ajaj, S. A., Jafari, A. A. A., Saeed, H., Khan, Z., and Khan, A. P., “Association of BRCA2 variants with cardiovascular disease in Saudi Arabia”, vol. 13, pp. 3876-3884, 2014.

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a multi-ethnic population. We examined the association between these BRCA2 polymorphisms and traits of CVD patients from Saudi Arabia. We genotyped rs11571836 and rs1799943 in 159 unrelated CVD patients and 176 healthy controls.

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