Single nucleotide polymorphisms

Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature

Y. Yang, Huang, H., Wang, W., Yang, L., Xie, L. L., and Huang, W., Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature, vol. 12, pp. 4768-4779, 2013.

The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyped. Preliminary screening revealed that the rs1976667 and rs2684788 loci were significantly associated with genetic susceptibility to ISS (P = 0.03636 and P = 0.01352, respectively).

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