Small-interfering RNA

Effect of siRNA targeting HER2/neu on the proliferation and viability of prostate cancer PC-3M cells

C. Y. Liu, Xu, P. C., Chen, D. G., Fan, X. H., Li, M. Q., Yang, X., and Xu, Y. P., Effect of siRNA targeting HER2/neu on the proliferation and viability of prostate cancer PC-3M cells, vol. 14, pp. 17145-17153, 2015.

The aim of this study was to investigate the effect of a small interfering RNA (siRNA) targeting human epidermal growth factor receptor 2 (HER2/neu) on the proliferation and viability of prostate cancer PC-3M cells. Chemically synthesized siRNA targeting HER2/neu was transfected into PC-3M cells by using liposomes, and cells transfected with empty liposomes, a negative siRNA sequence, or nothing (untransfected) were used as controls. mRNA and protein levels of HER2/neu were detected using reverse transcription-polymerase chain reaction and western blot, respectively.

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