Effect of siRNA targeting HER2/neu on the proliferation and viability of prostate cancer PC-3M cells
“Effect of siRNA targeting HER2/neu on the proliferation and viability of prostate cancer PC-3M cells”, vol. 14, pp. 17145-17153, 2015.
, The aim of this study was to investigate the effect of a small interfering RNA (siRNA) targeting human epidermal growth factor receptor 2 (HER2/neu) on the proliferation and viability of prostate cancer PC-3M cells. Chemically synthesized siRNA targeting HER2/neu was transfected into PC-3M cells by using liposomes, and cells transfected with empty liposomes, a negative siRNA sequence, or nothing (untransfected) were used as controls. mRNA and protein levels of HER2/neu were detected using reverse transcription-polymerase chain reaction and western blot, respectively.