Smoking

Distinct non-cerebrovascular risk factors for ischemic lacunar stroke and non-lacunar stroke: preliminary results

Y. F. Chen, Luo, C. H., Liu, Y. J., Lu, W. H., and Su, B. R., Distinct non-cerebrovascular risk factors for ischemic lacunar stroke and non-lacunar stroke: preliminary results, vol. 14, pp. 3170-3176, 2015.

Stroke is a non-communicable disease of increasing socioeconomic importance in aging populations. This study compared the risk factors implicated in two subtypes of ischemic stroke: lacunar stroke (LS) and non-lacunar stroke (NLS). A retrospective case control study was conducted on a total of 368 patients [220 cases (59.8%) of NLS and 148 cases (40.2%) of LS] with first-time onset of ischemic stroke. Multivariate logistic regression was performed to compare multiple non-cerebrovascular risk factors between the two groups.

Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking

T. M. Silva, Marques, C. R., Filho, M. F. Marques, Marques, A. B., Di Pietro, G., and Rios-Santos, F., Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking, vol. 13, pp. 528-537, 2014.

Polymorphisms in genes encoding xenobiotic-metabolizing enzymes might explain differences in the susceptibility to upper aerodigestive tract (UADT) cancers in individuals exposed to tobacco or other carcinogens. The present study aimed to evaluate the association of polymorphisms in the glutathione S-transferase (GST) candidate genes GSTM1, GSTT1, and GSTP1 with the risk of UADT cancers. GST gene polymorphisms were determined in 116 individuals with UADT cancer and 224 healthy controls using polymerase chain reaction-based methods.

The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy

Z. C. Wang, Shi, J. G., Chen, X. S., Xu, G. H., Li, L. J., and Jia, L. S., The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy, vol. 11, pp. 1238-1244, 2012.

We investigated a possible association of collagen IX tryptophan (Trp) alleles (Trp2 and Trp3) and smoking with cervical spondylotic myelopathy (CSM) in 172 Chinese patients and 176 age- and gender-matched controls. The smoking status was evaluated by smoking index (SI). The CSM cases had a significantly higher prevalence of Trp2 alleles (Trp2+) than controls (19.8 vs 6.2%, P = 0.002), but the prevalence of Trp3 alleles (Trp3+) was similar between the two groups (23.3 vs 21.6%, P = 0.713).

Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease

A. I. Güney, Ergec, D., Kırac, D., Ozturhan, H., Caner, M., Koc, G., Kaspar, C., Ulucan, K., and Agirbasli, M., Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease, vol. 12, pp. 6895-6906, 2013.

Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk factors is not well understood in CAD, likely due to the complex interrelation of genetic and environmental risk factors.

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