SNP

Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene

G. Rincón, Young, A. E., Bannasch, D. L., and Medrano, J. F., Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene, vol. 6, pp. 144-151, 2007.

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized the canine SOCS2 gene and analyzed its genetic diversity among small and large dog breeds. The study was carried out on a total of 520 dogs from 66 different breeds.

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