TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese
, “TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese”, vol. 13, pp. 1497-1507, 2014.
In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 gene may affect gene expression and biosynthesis of 5-HT triggering to various neuropsychiatric disorders related to 5-HT dysfunction.
