SNP

Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon

E. B. Machado, Souza, B. B., Guimarães, R. C., Azevedo, J. S. N., Gonçalves, E. C., Ribeiro, H. F. L., Filho, S. T. Rolim, E. Filho, S., Machado, E. B., Souza, B. B., Guimarães, R. C., Azevedo, J. S. N., Gonçalves, E. C., Ribeiro, H. F. L., Filho, S. T. Rolim, and E. Filho, S., Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon, vol. 15, p. -, 2016.

Buffalo farming in Brazil is increasing, as is the challenge of identifying molecular markers that will improve productivity. Therefore, the aim of this study was to analyze single nucleotide polymorphisms of the receptor gene for the hormone melatonin in buffaloes from northern Brazil by polymerase chain reactions (PCRs) and restriction fragment length polymorphism assays. The PCR products exhibited a cutting point for HpaI at the 318th position of the gene, indicating a transition substitution (T↔C).

A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice

X. Wang, Song, Z. G., Huang, D. X., Gao, H., Wang, Q., Wang, Z. P., Wang, X., Song, Z. G., Huang, D. X., Gao, H., Wang, Q., and Wang, Z. P., A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice, vol. 15, p. -, 2016.

GABAA receptors are chloride channels in the brain that are activated by binding with g-aminobutyric acid (GABA). The cDNA sequences of GABAA receptor subunits from two strains of mice with different sensitivities to isoflurane were compared to identify nucleotide mutations. Included 80 mice from two strains with different sensitivities to isoflurane on C57BL/6 background. Forty mice were from an isoflurane-sensitive strain (S group) and 40 mice were from a resistant strain (R group).

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