Genomic association study for adaptability traits in four Colombian cattle breeds
Polymorphism V362F (rs2304256) of tyrosine kinase 2 is not associated with childhood- or adulthood-onset type 1 diabetes in southern Brazil
Single Nucleotide Polymorphisms associated with growth and carcass traits located on QTL Regions previously associated with Bovine Respiratory Disease
Development of coding single nucleotide polymorphic markers in the pearl oyster Pinctada fucata based on next-generation sequencing and high-resolution melting analysis
CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects diarthrodial joints. RA affects ∼1% of the world’s population and is characterized by synovial hyperplasia, infiltration of large numbers of inflammatory cells into the joints, production of autoantibodies, systemic inflammation, and cardiovascular complications (McInnes and Schett, 2011; Arend and Firestein, 2012).
Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer
The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 participants; the cancer-free control subjects were 26-72 years old (41 ± 11.03) and the BC patients were 28-80 years old (51 ± 10.70).
Evaluation of associations between single nucleotide polymorphisms in the FRMD3 and CARS genes and diabetic nephropathy in a Kuwaiti population
Diabetic nephropathy is the leading cause of end-stage kidney disease in the world. Many single nucleotide polymorphisms (SNPs) have been associated with diabetic nephropathy. SNPs at the 4.1 protein ezrin, radixin, moesin domain 3 (FRMD3) and cysteinyl t-RNA synthetase (CARS) genes have a well-established relationship with diabetic nephropathy. However, this association has not been evaluated in a Kuwaiti population.
Genetic polymorphisms in very important pharmacogenomic (VIP) variants in the Tibetan population
Genetic polymorphisms of very important pharmacogenomic (VIP) variants are important for personalized medicine. However, these have not been extensively studied in the Tibetan population. In this study, 82 VIP variants were detected in the Tibetan and Han (HAN) populations from northwestern China.
Analysis of SNP (single nucleotide polymorphism) multiplex markers related to sudden cardiac death in Brazilian families
Sudden cardiac death (SCD) is a major public health concern worldwide, and genetic analysis may be useful in identifying the cause of death as well as in determining the possible genetic risk factors for SCD. This study analyzed eight SNPs (single nucleotide polymorphisms) highly correlated with cardiac sudden death in samples (blood and bone) from six Brazilian families with a history of cardiovascular diseases. Individuals with no family history of cardiovascular diseases were recruited as controls.