SNPs

Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

M. Y. Zhao, Xue, Y., Zhao, Z. Q., Li, F. J., Fan, D. P., Wei, L. L., Sun, X. J., Zhang, X., Wang, X. C., Zhang, Y. X., and Li, J. C., Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population, vol. 11, pp. 3425-3431, 2012.

Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a Chinese Han population in a case-control study of 432 Chinese patients with tuberculosis and 404 ethnically matched healthy controls.

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