SNPs

Role of XRCC1 and ERCC5 polymorphisms on clinical outcomes in advanced non-small cell lung cancer

D. Liu, Wu, J., Shi, G. Y., Zhou, H. F., and Yu, Y., “Role of XRCC1 and ERCC5 polymorphisms on clinical outcomes in advanced non-small cell lung cancer”, vol. 13, pp. 3100-3107, 2014.

We aimed to assess the role of polymorphisms of the XRCC1 Arg194Trp, XRCC1 Arg399Gln, ERCC5 His1104Asp, and ERCC5 His46His genes on clinical outcomes of advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy regimens. A total of 378 NSCLC patients were asked to participate within 1 month after diagnosis between January 2005 and January 2006, and they were followed up until November 2011. Genomic DNA of the four genes was extracted using the Qiagen Blood Kit.

A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer

X. X. Lu, Hu, J. J., Fang, Y., Wang, Z. T., Xie, J. J., Zhan, Q., Deng, X. X., Chen, H., Jin, J. B., Peng, C. H., Liu, J., Li, H. W., and Shen, B. Y., “A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer”, vol. 13, pp. 6142-6147, 2014.

Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped 3 single nucleotide polymorphisms (rs2980879, rs2980874, and rs2235108) of the TRIB1 gene in 182 patients and 359 normal controls of Chinese Han origin and analyzed their association.

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