SNPs

Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia

S. - Q. Ge, Grifin, J., Liu, L. - H., Aston, K. I., Simon, L., Jenkins, T. G., Emery, B. R., and Carrell, D. T., Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia, vol. 14, pp. 9053-9061, 2015.

Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility. The aim of this study was to identify mutations in Pygo2 that might lead to idiopathic oligospermia and azoospermia. DNA was isolated from venous blood from 77 men with normal fertility and 195 men with idiopathic oligospermia or azoospermia.

Comparison of methods used to identify superior individuals in genomic selection in plant breeding

L. L. Bhering, Junqueira, V. S., Peixoto, L. A., Cruz, C. D., and Laviola, B. G., Comparison of methods used to identify superior individuals in genomic selection in plant breeding, vol. 14, pp. 10888-10896, 2015.

The aim of this study was to evaluate different methods used in genomic selection, and to verify those that select a higher proportion of individuals with superior genotypes. Thus, F2 populations of different sizes were simulated (100, 200, 500, and 1000 individuals) with 10 replications each. These consisted of 10 linkage groups (LG) of 100 cM each, containing 100 equally spaced markers per linkage group, of which 200 controlled the characteristics, defined as the 20 initials of each LG.

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