Somatic mutation

Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome

X. Z. Chen, Fang, Y., Shi, Y. H., Cui, J. H., Li, L. Y., Xu, Y. C., and Ling, B., “Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome”, vol. 14, pp. 4331-4337, 2015.

The mitochondrion is a crucial intracellular organelle responsible for regulating cellular energy metabolism, producing free radicals, initiating and executing the apoptotic pathways. Previous studies have shown that somatic mutations in mitochondrial DNA are associated with various tumors, which may be involved during carcinogenesis and tumor progression. To examine the mutation pattern in cancer, 625 reported somatic mutations in the mitochondrial DNA genome were analyzed.

Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China

Y. Fang, Yang, H. Y., Shi, Y. H., Cui, J. H., Li, L. Y., Xu, Y. C., and Shao, J. L., “Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China”, vol. 14, pp. 5031-5043, 2015.

Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactors in the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-cancerous normal and distant normal tissues for 79 Chinese patients with lung cancer were analyzed in this study.

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